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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmcADomain of unknown function DUF1726; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (814 aa)    
Predicted Functional Partners:
ADV65170.1
COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR012976: IPR002687; KEGG: dka:DKAM_0815 C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; SPTR: Pre-mRNA processing ribonucleoprotein, binding region; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain.
   
 
 0.999
ADV65405.1
KH domain protein; COGs: COG1094 RNA-binding protein (contains KH domains); InterPro IPR019964: IPR018111: IPR004087; KEGG: dka:DKAM_1088 putative RNA-processing protein; PFAM: K Homology, type 1, subgroup; SPTR: Predicted RNA-binding protein (Contains KH domains); TIGRFAM: KH domain protein; PFAM: KH domain; TIGRFAM: arCOG04150 universal archaeal KH domain protein.
   
 
 0.999
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
   
 
 0.930
nep1
Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
  
 
 0.905
rpl7ae
LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
 
 
 0.878
ADV65566.1
Small GTP-binding protein; COGs: COG1084 GTPase; InterPro IPR002917: IPR006073: IPR005225; KEGG: dka:DKAM_1284 small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; SPTR: Small GTP-binding protein; TIGRFAM: small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
  
 
 0.809
ADV64559.1
AAA family ATPase, CDC48 subfamily; COGs: COG0464 ATPase of the AAA+ class; InterProIPR003960: IPR003593: IPR005938: IPR003338: IPR 004201: IPR003959; KEGG: dka:DKAM_0042 cell division control protein 48, AAA family; PFAM: AAA ATPase central domain protein; AAA ATPase VAT domain protein; cell division protein 48 CDC48 domain 2; PRIAM: Microtubule-severing ATPase; SMART: AAA ATPase; SPTR: Cell division control protein 48, AAA family; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: Cell division protein 48 (CDC48), N-terminal domain; ATPase family associated with various cellular acti [...]
  
  
 0.808
rps6e
COGs: COG2125 Ribosomal protein S6E (S10); InterPro IPR001377: IPR018282; KEGG: dka:DKAM_1348 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; SPTR: 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
  
 
 0.805
rps15
COGs: COG0184 Ribosomal protein S15P/S13E; InterPro IPR012606: IPR000589; KEGG: dka:DKAM_1338 30S ribosomal protein S15P; PFAM: Ribosomal S13S15 domain protein; ribosomal protein S15; SPTR: 30S ribosomal protein S15P/S13e; PFAM: Ribosomal S13/S15 N-terminal domain; Ribosomal protein S15.
  
 
 0.800
rps28e
COGs: COG2053 Ribosomal protein S28E/S33; InterPro IPR000289; KEGG: dka:DKAM_1351 30S ribosomal protein S28e; PFAM: Ribosomal protein S28e; SPTR: 30S ribosomal protein S28e; PFAM: Ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.
   
   0.799
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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