close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV64581.1NUDIX hydrolase; COGs: COG1051 ADP-ribose pyrophosphatase; InterPro IPR020084: IPR020476: IPR000086; KEGG: dka:DKAM_0750 ADP-ribose pyrophosphatase; PFAM: NUDIX hydrolase; SPTR: ADP-ribose pyrophosphatase; PFAM: NUDIX domain. (175 aa)    
Predicted Functional Partners:
ADV64582.1
Hypothetical protein; InterPro IPR010916; KEGG: dka:DKAM_0751 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1393).
  
    0.613
ADV64580.1
NADPH-dependent FMN reductase; COGs: COG0655 Multimeric flavodoxin WrbA; InterPro IPR005025; KEGG: dka:DKAM_0749 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase.
  
  
 0.608
ADV64583.1
ABC transporter related protein; COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR017871: IPR018120: IPR003439: IPR003593; KEGG: dka:DKAM_0752 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter related; PFAM: ABC transporter.
       0.504
ADV64584.1
KEGG: dka:DKAM_0753 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.504
ADV64410.1
NUDIX hydrolase; InterPro IPR020084: IPR020476: IPR000086; KEGG: dka:DKAM_0987 ADP-ribose pyrophosphatase; PFAM: NUDIX hydrolase; SPTR: ADP-ribose pyrophosphatase; PFAM: NUDIX domain.
  
  
 0.465
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.459
ADV65043.1
DNA-(apurinic or apyrimidinic site) lyase; COGs: COG0177 EndoIII-related endonuclease; InterPro IPR004035: IPR003265: IPR003651; KEGG: dka:DKAM_0329 endonuclease III; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SMART: HhH-GPD family protein; iron-sulfur cluster loop; SPTR: Endonuclease III; PFAM: HhH-GPD superfamily base excision DNA repair protein; Iron-sulfur binding domain of endonuclease III.
     
 0.456
ADV65147.1
COGs: COG0167 Dihydroorotate dehydrogenase; InterPro IPR005720: IPR017900: IPR012135: IPR017896; KEGG: dka:DKAM_0183 dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate oxidase; SPTR: Dihydroorotate dehydrogenase family protein; TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: Dihydroorotate dehydrogenase; 4Fe-4S binding domain; TIGRFAM: dihydroorotate dehydrogenase (subfamily 1) family protein.
  
  
 0.453
ADV65622.1
KEGG: dka:DKAM_1337 phosphoesterase, RecJ domain protein; SPTR: Phosphoesterase, RecJ domain protein.
  
  
 0.426
ADV65624.1
dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.420
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.