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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV64764.1COGs: COG3379 conserved hypothetical protein; InterPro IPR002591; KEGG: smr:Smar_1366 type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: type I phosphodiesterase/nucleotide pyrophosphatase; SPTR: Type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: Type I phosphodiesterase / nucleotide pyrophosphatase. (716 aa)    
Predicted Functional Partners:
ADV64765.1
COGs: COG1254 Acylphosphatase; InterPro IPR001792: IPR020456: IPR017968; KEGG: kcr:Kcr_0367 acylphosphatase; PFAM: acylphosphatase; SPTR: Acylphosphatase; PFAM: Acylphosphatase.
       0.567
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
     
 0.523
ADV64671.1
SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR013134: IPR003593: IPR003395; KEGG: dka:DKAM_0610 DNA double-strand break repair rad50 ATPase; PFAM: SMC domain protein; SMART: AAA ATPase; SPTR: DNA double-strand break repair rad50 ATPase.
 
    0.426
ADV65444.1
COGs: COG1091 dTDP-4-dehydrorhamnose reductase; InterPro IPR005913; KEGG: tag:Tagg_0561 dTDP-4-dehydrorhamnose reductase; PFAM: dTDP-4-dehydrorhamnose reductase; SPTR: dTDP-4-dehydrorhamnose reductase; TIGRFAM: dTDP-4-dehydrorhamnose reductase; PFAM: RmlD substrate binding domain; TIGRFAM: dTDP-4-dehydrorhamnose reductase.
 
     0.425
ADV64383.1
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; COGs: COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; InterPro IPR000537; KEGG: dka:DKAM_1012 UbiA prenyltransferase; PFAM: UbiA prenyltransferase; PRIAM: Geranylgeranylglycerol-phosphate geranylgeranyltransferase; SPTR: ORF 1; PFAM: UbiA prenyltransferase family.
     
 0.422
ppa
Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
     
 0.409
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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