Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
ADV64774.1hydroxymethylglutaryl-CoA reductase, degradative; COGs: COG1257 Hydroxymethylglutaryl-CoA reductase; InterPro IPR002202: IPR004553; KEGG: dka:DKAM_0720 hydroxymethylglutaryl-CoA reductase, degradative; PRIAM: Hydroxymethylglutaryl-CoA reductase (NADPH); SPTR: Hydroxymethylglutaryl-CoA reductase, degradative; TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (426 aa)    
Predicted Functional Partners:
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 0.995
ADV65101.1
COGs: COG3425 3-hydroxy-3-methylglutaryl CoA synthase; InterPro IPR004656: IPR019775: IPR013747; KEGG: dka:DKAM_0390 hypothetical protein; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain-containing protein; SPTR: 3-hydroxy-3-methylglutaryl CoA synthase; TIGRFAM: hydroxymethylglutaryl-CoA synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; TIGRFAM: hydroxymethylglutaryl-CoA synthase, putative; Belongs to the thiolase-like superfamily. UPF0219 family.
  
 
 0.986
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
    
 0.812
ADV64772.1
ATPase-like, ParA/MinD; COGs: COG0489 ATPase involved in chromosome partitioning; InterPro IPR019591; KEGG: dka:DKAM_0718 nucleotide-binding protein, mrp/nbp35 family; PFAM: ATPase-like, ParA/MinD; SPTR: Nucleotide-binding protein, mrp/nbp35 family; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.
       0.667
ADV64773.1
COGs: COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); InterPro IPR000688; KEGG: dka:DKAM_0719 hydrogenase nickel incorporation protein; PFAM: hydrogenase expression/synthesis HypA; SPTR: Probable hydrogenase nickel incorporation protein; PFAM: Hydrogenase expression/synthesis hypA family.
       0.667
ADV64467.1
Polyprenyl synthetase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: dka:DKAM_1455 polyprenyl synthetase; PFAM: Polyprenyl synthetase; SPTR: Polyprenyl synthetase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
  
 
 0.643
ADV64775.1
KEGG: dka:DKAM_0345 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.516
ADV64874.1
COGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterPro IPR014732: IPR001754; KEGG: dka:DKAM_0477 orotidine-5'-phosphate decarboxylase, PyrF; PFAM: Orotidine 5'-phosphate decarboxylase; SPTR: Orotidine-5'-phosphate decarboxylase, PyrF; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 1.
     
 0.434
ADV64415.1
Heavy metal translocating P-type ATPase; COGs: COG2217 Cation transport ATPase; InterProIPR018303: IPR006121: IPR006416: IPR001757: IPR 008250: IPR005834; KEGG: tag:Tagg_1238 heavy metal translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; SPTR: Heavy metal translocating P-type ATPase; TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; haloacid dehalogenase-like hydrolase; TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type [...]
     
 0.422
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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