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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hjcResolvase, Holliday junction-type; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (144 aa)    
Predicted Functional Partners:
ADV64811.1
Metallophosphoesterase; COGs: COG3889 solute binding protein; InterPro IPR003529: IPR004843; KEGG: dka:DKAM_0637 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase.
       0.662
ADV64709.1
ERCC4 domain protein; COGs: COG1948 ERCC4-type nuclease; InterPro IPR006166: IPR000445; KEGG: dka:DKAM_0676 ERCC4 domain protein; PFAM: ERCC4 domain protein; helix-hairpin-helix motif; SPTR: ERCC4 domain protein; PFAM: Helix-hairpin-helix motif.
  
     0.552
ADV64813.1
COGs: COG1855 ATPase (PilT family); InterPro IPR006596: IPR003593; KEGG: dka:DKAM_0634 ATPase; SMART: Nucleotide binding protein PINc; AAA ATPase; SPTR: PilT protein domain protein; PFAM: Type II/IV secretion system protein.
 
   
 0.552
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
 
   
 0.546
kae1
Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family.
     
 0.508
ADV64321.1
ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication.
      
 0.499
hel308
DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
      
 0.499
ADV65164.1
COGs: COG3357 transcriptional regulator protein; KEGG: dka:DKAM_0809 predicted transcriptional regulator consisting of an HTH domain fused to a Zn-ribbon; SPTR: Predicted transcriptional regulator consisting of an HTH domain fused to a Zn-ribbon.
  
     0.460
ADV64810.1
Protein of unknown function DUF2223; COGs: COG4945 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase; InterPro IPR019248; KEGG: dka:DKAM_0638 membrane-anchored protein predicted to be involved in regulation of amylopullulanase-like protein; PFAM: Protein of unknown function DUF2223; SPTR: Membrane-anchored protein predicted to be involved in regulation of amylopullulanase-like protein; PFAM: Domain of unknown function (DUF2223).
       0.439
ADV65577.1
COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR006172: IPR006133: IPR006134: IPR017966: IPR 004578: IPR017964; KEGG: dka:DKAM_1295 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B; SPTR: DNA polymerase; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; TIGRFAM: DNA polymerase (pol2).
 
  
 0.429
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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