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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ADV64929.1PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR000541: IPR012089: IPR011063; KEGG: dka:DKAM_0492 predicted ATPase of the PP-loop superfamily; PFAM: PP-loop domain protein; SPTR: Predicted ATPase of the PP-loop superfamily; PFAM: PP-loop family; TIGRFAM: conserved hypothetical protein TIGR00269. (339 aa)    
Predicted Functional Partners:
ADV64330.1
KEGG: dka:DKAM_1386 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: ThiS family.
  
 
 0.748
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
  
 0.700
ADV65593.1
COGs: COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferase; InterPro IPR014816; KEGG: dka:DKAM_1308 methyltransferase type 11; PFAM: tRNA methyltransferase complex GCD14 subunit; PRIAM: tRNA (adenine-N(1)-)-methyltransferase; SPTR: Methyltransferase type 11; PFAM: tRNA methyltransferase complex GCD14 subunit.
 
  
 0.663
ADV64876.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR017926: IPR006220: IPR011702: IPR004739: IPR 001674: IPR000991; KEGG: dka:DKAM_0479 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
  
  
 0.613
ADV64331.1
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594: IPR007901; KEGG: dka:DKAM_1387 MoeB/ThiF molybdopterin or thiamine synthase protein; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: MoeB/thiF molybdopterin or thiamine synthase protein; PFAM: MoeZ/MoeB domain; ThiF family.
 
 
 0.570
ADV64930.1
Metallophosphoesterase; COGs: COG2129 phosphoesterase related to the Icc protein; InterPro IPR004843; KEGG: dka:DKAM_0491 metallophosphoesterase, calcineurin superfamily; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase, calcineurin superfamily; PFAM: Calcineurin-like phosphoesterase.
       0.565
ADV65393.1
tRNA pseudouridine synthase D TruD; COGs: COG0585 conserved hypothetical protein; InterPro IPR001656: IPR011760; KEGG: dka:DKAM_1075 tRNA pseudouridine synthase D; PFAM: tRNA pseudouridine synthase D TruD; SPTR: tRNA pseudouridine synthase D; PFAM: tRNA pseudouridine synthase D (TruD); TIGRFAM: tRNA pseudouridine synthase, TruD family.
 
 
 0.506
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
 
 
 
 0.487
ADV65572.1
COGs: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2; InterPro IPR001179; KEGG: dka:DKAM_1290 peptidylprolyl isomerase, FKBP-type; PFAM: peptidylprolyl isomerase FKBP-type; SPTR: Peptidylprolyl isomerase, FKBP-type; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase.
 
     0.462
ADV64931.1
Transporter, YbiR family; COGs: COG1055 Na+/H+ antiporter NhaD and related arsenite permease; InterPro IPR004680: IPR000802; KEGG: dka:DKAM_0318 transport protein; PFAM: Citrate transporter; SPTR: Transport protein; PFAM: Citrate transporter.
       0.461
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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