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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV64952.1COGs: COG0031 Cysteine synthase; InterPro IPR001216: IPR001926; KEGG: tag:Tagg_1314 pyridoxal-5'-phosphate-dependent protein subunit beta; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme. (405 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.957
ADV65163.1
COGs: COG0560 Phosphoserine phosphatase; InterPro IPR006383: IPR005834; KEGG: dka:DKAM_0808 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Phosphoserine phosphatase; TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; HAD-superfamily, subfamily-IB PSPase-like hydrolase, archaeal.
    
 0.949
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.942
ADV65033.1
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004838: IPR004839: IPR001176; KEGG: dka:DKAM_0468 aspartate aminotransferase (AspC), conjectural; PFAM: aminotransferase class I and II; SPTR: Aspartate aminotransferase (AspC), conjectural; PFAM: Aminotransferase class I and II.
 
 0.941
ADV65208.1
InterPro IPR003115; KEGG: dka:DKAM_0858 ParB domain protein nuclease; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: ParB domain protein nuclease; PFAM: ParB-like nuclease domain.
    
 0.929
ADV65088.1
COGs: COG0031 Cysteine synthase; InterPro IPR001216: IPR001926; KEGG: dka:DKAM_0378 pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme.
  
  
 
0.926
trpB
Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
ADV65046.1
COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR005252: IPR003382: IPR007085; KEGG: dka:DKAM_0332 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein; SPTR: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothen [...]
    
 0.824
ADV64876.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR017926: IPR006220: IPR011702: IPR004739: IPR 001674: IPR000991; KEGG: dka:DKAM_0479 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
  
  
 0.675
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.652
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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