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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (141 aa)    
Predicted Functional Partners:
ADV64984.1
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027: IPR004099: IPR000815; KEGG: dka:DKAM_0296 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
 
  
 0.999
gcvPB
Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
 
 0.999
ADV64987.1
Aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR006223: IPR006222: IPR013977; KEGG: dka:DKAM_0299 glycine cleavage system aminomethyltransferase T; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; SPTR: Aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; TIGRFAM: glycine cleavage system T protein.
 
 0.999
gcvPA
Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
  
 0.997
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.993
ADV64525.1
COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: dka:DKAM_0075 lipoate-protein ligase A; PFAM: biotin/lipoate A/B protein ligase; SPTR: Lipoate-protein ligase a; PFAM: Biotin/lipoate A/B protein ligase family.
   
 0.912
ADV64526.1
KEGG: dka:DKAM_0074 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Bacterial lipoate protein ligase C-terminus.
   
 0.912
ADV64485.1
COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: tag:Tagg_0520 glutamine synthetase catalytic region; PFAM: glutamine synthetase catalytic region; SPTR: Glutamine synthetase catalytic region; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain.
  
 
 0.851
ADV64465.1
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006095: IPR014362: IPR006097: IPR006096; KEGG: dka:DKAM_1451 Glu/Leu/Phe/Val dehydrogenase, C terminal; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: Glu/Leu/Phe/Val dehydrogenase, C terminal; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.809
ADV64380.1
Sulfide dehydrogenase (flavoprotein) subunit SudA; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027: IPR000103; KEGG: dka:DKAM_1015 putative glutamate synthase subunit beta; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Putative glutamate synthase subunit beta; PFAM: Pyridine nucleotide-disulphide oxidoreductase.
    
 0.806
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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