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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (285 aa)    
Predicted Functional Partners:
speH
Adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
 
 
 0.996
ADV64546.1
Agmatinase; COGs: COG0010 Arginase/agmatinase/formimionoglutamate hydrolase arginase family; InterPro IPR020855: IPR006035: IPR005925; KEGG: dka:DKAM_0053 agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; SPTR: Agmatinase; TIGRFAM: agmatinase; PFAM: Arginase family; TIGRFAM: agmatinase; Belongs to the arginase family.
  
 
 0.964
mtnP
Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
  
 
 0.944
ADV64475.1
Amidohydrolase; COGs: COG0402 Cytosine deaminase and related metal-dependent hydrolase; InterPro IPR006680; KEGG: dka:DKAM_0010 amidohydrolase; PFAM: amidohydrolase; SPTR: Amidohydrolase; PFAM: Amidohydrolase family.
  
  0.911
ADV65245.1
Amidohydrolase; COGs: COG0402 Cytosine deaminase and related metal-dependent hydrolase; InterPro IPR006680; KEGG: dka:DKAM_0243 amidohydrolase; PFAM: amidohydrolase; SPTR: Amidohydrolase; PFAM: Amidohydrolase family.
  
  0.911
ADV64335.1
COGs: COG2820 Uridine phosphorylase; InterPro IPR018016: IPR000845; KEGG: dka:DKAM_0803 purine and other phosphorylase, family 1; PFAM: purine or other phosphorylase family 1; SPTR: Purine and other phosphorylase, family 1; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD).
     
  0.900
ADV65158.1
COGs: COG2820 Uridine phosphorylase; InterPro IPR018016: IPR000845; KEGG: dka:DKAM_0803 purine and other phosphorylase, family 1; PFAM: purine or other phosphorylase family 1; SPTR: Purine and other phosphorylase, family 1; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD).
     
  0.900
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
     
 0.870
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
     
 0.639
ADV64992.1
COGs: COG4697 conserved hypothetical protein; KEGG: tag:Tagg_0104 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein conserved in archaea (DUF2139).
       0.615
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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