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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmkCOGs: COG0125 Thymidylate kinase; InterPro IPR018094: IPR018095: IPR000062; KEGG: dka:DKAM_0141 thymidylate kinase; PFAM: thymidylate kinase; PRIAM: dTMP kinase; SPTR: Probable thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (204 aa)    
Predicted Functional Partners:
thyX
Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.925
ADV65000.1
Protein of unknown function DUF126; COGs: COG1786 conserved hypothetical protein; InterPro IPR002840; KEGG: dka:DKAM_0142 putative aconitase, subunit; PFAM: protein of unknown function DUF126; SPTR: Putative aconitase, subunit; PFAM: Protein of unknown function DUF126.
       0.880
ADV65001.1
Putative aconitase subunit 1; COGs: COG1679 conserved hypothetical protein; InterPro IPR007506; KEGG: dka:DKAM_0143 putative aconitase subunit 1; PFAM: protein of unknown function DUF521; SPTR: Putative aconitase subunit 1; PFAM: Protein of unknown function (DUF521).
       0.793
ADV65002.1
Carboxylyase-related protein; COGs: COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylase; InterPro IPR017871: IPR002830; KEGG: dka:DKAM_0144 UbiD family decarboxylase; PFAM: Carboxylyase-related protein; SPTR: UbiD family decarboxylase; PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylases.
       0.772
ADV65003.1
COGs: COG1341 GTPase or GTP-binding protein; KEGG: dka:DKAM_0145 putative GTPase or GTP-binding protein; SPTR: Putative GTPase or GTP-binding protein; PFAM: Molybdopterin guanine dinucleotide synthesis protein B.
       0.772
ADV65004.1
KEGG: dka:DKAM_0146 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.752
rfcL
Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
  
 
 0.673
rfcS
Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily.
  
 
 0.673
ADV64874.1
COGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterPro IPR014732: IPR001754; KEGG: dka:DKAM_0477 orotidine-5'-phosphate decarboxylase, PyrF; PFAM: Orotidine 5'-phosphate decarboxylase; SPTR: Orotidine-5'-phosphate decarboxylase, PyrF; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 1.
 
   
 0.599
ADV65005.1
AAA ATPase; COGs: COG0468 RecA/RadA recombinase; InterPro IPR003593; KEGG: dka:DKAM_0147 AAA ATPase; SMART: AAA ATPase; SPTR: AAA ATPase.
  
 
 0.585
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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