Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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dysDeoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (326 aa)    
Predicted Functional Partners:
tiaS
tRNA(Ile2) 2-agmatinylcytidine synthetase; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
     
 0.922
eif5a
Translation initiation factor 5A precursor (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
   
 0.899
ADV65033.1
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004838: IPR004839: IPR001176; KEGG: dka:DKAM_0468 aspartate aminotransferase (AspC), conjectural; PFAM: aminotransferase class I and II; SPTR: Aspartate aminotransferase (AspC), conjectural; PFAM: Aminotransferase class I and II.
     
 0.804
rpl6
LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
   0.631
ADV65036.1
KEGG: dka:DKAM_0471 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.624
top6A
DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
     
 0.621
ADV65031.1
Metal dependent phosphohydrolase; COGs: COG1896 hydrolase of HD superfamily; InterPro IPR006674: IPR003607; KEGG: dka:DKAM_0466 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Metal dependent phosphohydrolase; PFAM: HD domain.
  
    0.505
pcn-2
DNA polymerase sliding clamp subunit A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
     0.501
ADV65032.1
Conserved carboxylase region; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000891: IPR003379; KEGG: dka:DKAM_0467 pyruvate/oxaloacetate carboxyltransferase; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; SPTR: Pyruvate/oxaloacetate carboxyltransferase; PFAM: HMGL-like; Conserved carboxylase domain.
       0.483
ADV64923.1
Arginine--tRNA ligase; COGs: COG0018 Arginyl-tRNA synthetase; InterPro IPR015945: IPR008909; KEGG: dka:DKAM_0500 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; SPTR: Arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; tRNA synthetases class I (R); Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.442
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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