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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (268 aa)    
Predicted Functional Partners:
ADV65054.1
Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
   
 0.993
ADV65055.1
Phosphomethylpyrimidine kinase; COGs: COG1992 conserved hypothetical protein; InterPro IPR019293; KEGG: dka:DKAM_0343 transcriptional regulator, fis family; PFAM: Phosphomethylpyrimidine kinase; SPTR: Transcriptional regulator, Fis family; PFAM: Archaeal phosphomethylpyrimidine kinase.
       0.770
ADV65056.1
KEGG: dka:DKAM_0344 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.769
ADV64876.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR017926: IPR006220: IPR011702: IPR004739: IPR 001674: IPR000991; KEGG: dka:DKAM_0479 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
     
 0.746
ADV65046.1
COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR005252: IPR003382: IPR007085; KEGG: dka:DKAM_0332 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein; SPTR: Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothen [...]
 
   
 0.548
ADV65058.1
ABC-2 type transporter; COGs: COG1668 ABC-type Na+ efflux pump permease component; KEGG: dka:DKAM_0347 ABC-2 type transporter; SPTR: ABC-2 type transporter.
       0.548
ADV65057.1
ABC transporter related protein; COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR017871: IPR003439: IPR003593; KEGG: dka:DKAM_0346 daunorubicin resistance ATP-binding protein-like protein; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: Daunorubicin resistance ATP-binding protein-like protein; PFAM: ABC transporter.
       0.544
ADV64589.1
COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004408: IPR004143: IPR003142; KEGG: dka:DKAM_0757 biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; biotin protein ligase domain protein; SPTR: Biotin--acetyl-CoA-carboxylase ligase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: Biotin protein ligase C terminal domain; Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region.
  
  
 0.510
ADV65289.1
MATE efflux family protein; COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: dka:DKAM_0200 MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; SPTR: MATE efflux family protein; TIGRFAM: MATE efflux family protein; manually curated; PFAM: MatE; TIGRFAM: putative efflux protein, MATE family.
  
  
 0.441
ADV65049.1
COGs: COG1829 kinase (sugar kinase superfamily); InterPro IPR006204; KEGG: dka:DKAM_0337 kinase (sugar kinase superfamily)-like protein; PFAM: GHMP kinase; SPTR: Kinase (Sugar kinase superfamily)-like protein.
     
 0.437
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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