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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
flpArRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (235 aa)    
Predicted Functional Partners:
ADV64410.1
NUDIX hydrolase; InterPro IPR020084: IPR020476: IPR000086; KEGG: dka:DKAM_0987 ADP-ribose pyrophosphatase; PFAM: NUDIX hydrolase; SPTR: ADP-ribose pyrophosphatase; PFAM: NUDIX domain.
  
 0.999
ADV65170.1
COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR012976: IPR002687; KEGG: dka:DKAM_0815 C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; SPTR: Pre-mRNA processing ribonucleoprotein, binding region; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain.
 
 
 0.999
ADV65405.1
KH domain protein; COGs: COG1094 RNA-binding protein (contains KH domains); InterPro IPR019964: IPR018111: IPR004087; KEGG: dka:DKAM_1088 putative RNA-processing protein; PFAM: K Homology, type 1, subgroup; SPTR: Predicted RNA-binding protein (Contains KH domains); TIGRFAM: KH domain protein; PFAM: KH domain; TIGRFAM: arCOG04150 universal archaeal KH domain protein.
   
 0.999
nep1
Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
   
 0.999
rps5
SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy.
  
 0.999
rps6e
COGs: COG2125 Ribosomal protein S6E (S10); InterPro IPR001377: IPR018282; KEGG: dka:DKAM_1348 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; SPTR: 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
   
 0.999
rpl7ae
LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
  
 0.999
rps4
SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
 
 0.995
rps11
SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
  
 0.970
rpl13
LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
 
 
 0.946
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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