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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rgyReverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1326 aa)    
Predicted Functional Partners:
ADV65180.1
KEGG: dka:DKAM_0825 amidohydrolase-like protein; SPTR: Amidohydrolase-like protein.
       0.882
ADV65179.1
KEGG: dka:DKAM_0824 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.809
ADV65182.1
COGs: COG0591 Na+/proline symporter; InterPro IPR001734; KEGG: dka:DKAM_0827 sodium/solute symporter; PFAM: Na+/solute symporter; SPTR: Sodium/solute symporter; PFAM: Sodium:solute symporter family; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
       0.617
ADV65183.1
KEGG: dka:DKAM_0828 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.607
ADV65184.1
COGs: COG3888 transcriptional regulator protein; KEGG: dka:DKAM_0829 transcriptional regulator MarR family; SPTR: Transcriptional regulator MarR family.
       0.453
ADV65167.1
Nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
  
   
 0.419
ADV64560.1
Putative circadian clock protein, KaiC; COGs: COG0467 RecA-superfamily ATPase implicated in signal transduction; InterProIPR020588: IPR010624: IPR003593: IPR004504: IPR 014774; KEGG: dka:DKAM_0043 hypothetical protein; PFAM: Circadian clock protein KaiC central region; SMART: AAA ATPase; SPTR: Putative circadian clock protein, KaiC; PFAM: KaiC; TIGRFAM: KaiC domain protein, Ph0284 family; Belongs to the UPF0273 family.
 
     0.400
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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