close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV65195.1Protein of unknown function UPF0047; COGs: COG0432 conserved hypothetical protein; InterPro IPR001602; KEGG: dka:DKAM_0841 UPF0047 domain containing protein; PFAM: protein of unknown function UPF0047; SPTR: UPF0047 domain containing protein; PFAM: Uncharacterised protein family UPF0047; TIGRFAM: secondary thiamine-phosphate synthase enzyme. (138 aa)    
Predicted Functional Partners:
ADV65196.1
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR007229: IPR002638; KEGG: dka:DKAM_0842 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate phosphoribosyltransferase; SPTR: Quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: putative nicotinate phosphoribosyltransferase.
       0.882
ADV65194.1
Hypothetical protein; COGs: COG0071 Molecular chaperone (small heat shock protein); InterPro IPR017447: IPR002068; KEGG: dka:DKAM_0840 small heat shock protein HSP20; PFAM: CS; SPTR: Small heat shock protein Hsp20; PFAM: Hsp20/alpha crystallin family; Belongs to the small heat shock protein (HSP20) family.
       0.645
ADV65193.1
Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979: IPR004843; KEGG: dka:DKAM_0839 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family.
       0.585
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.512
ADV65191.1
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611: IPR002139; KEGG: dka:DKAM_0837 ATP-dependent 6-phosphofructokinase; PFAM: PfkB domain protein; SPTR: ATP-dependent 6-phosphofructokinase; PFAM: pfkB family carbohydrate kinase.
       0.505
ADV65192.1
COGs: COG2820 Uridine phosphorylase; InterPro IPR010058: IPR000845; KEGG: dka:DKAM_0838 uridine phosphorylase; PFAM: purine or other phosphorylase family 1; SPTR: Uridine phosphorylase; TIGRFAM: uridine phosphorylase; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD); uridine phosphorylase.
       0.505
ADV65189.1
KEGG: dka:DKAM_0835 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.472
ADV65190.1
KEGG: dka:DKAM_0836 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.461
thiL
Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
 
   
 0.401
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.