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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV65267.1COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterPro IPR004529: IPR002319: IPR006195; KEGG: dka:DKAM_0237 phenylalanyl-tRNA synthetase subunit alpha; PFAM: phenylalanyl-tRNA synthetase class IIc; SPTR: PheS; phenylalanyl-tRNA synthetase subunit alpha; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit. (514 aa)    
Predicted Functional Partners:
ADV65153.1
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterPro IPR004531: IPR005146: IPR005147: IPR002319; KEGG: dka:DKAM_0189 phenylalanyl-tRNA synthetase subunit beta; PFAM: tRNA synthetase B5; B3/4 domain protein; phenylalanyl-tRNA synthetase class IIc; PRIAM: Phenylalanine--tRNA ligase; SPTR: Phenylalanyl-tRNA synthetase subunit beta; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit.
 
 0.999
ADV65201.1
t-RNA-binding domain-containing protein; COGs: COG0073 EMAP domain; InterPro IPR002547; KEGG: dka:DKAM_0847 methionyl-tRNA synthetase, beta subunit; PFAM: t-RNA-binding domain-containing protein; SPTR: Methionyl-tRNA synthetase, beta subunit; PFAM: Putative tRNA binding domain; TIGRFAM: methionyl-tRNA synthetase C-terminal region/beta chain.
  
 
 0.999
rpl10e
COGs: COG0197 Ribosomal protein L16/L10E; InterPro IPR018255: IPR001197: IPR016180; KEGG: dka:DKAM_1411 50S ribosomal protein L10e; PFAM: Ribosomal protein L10e/L16; SPTR: 50S ribosomal protein L10e; PFAM: Ribosomal protein L16p/L10e; TIGRFAM: ribosomal protein L10.e; Belongs to the universal ribosomal protein uL16 family.
 
 0.869
ADV65268.1
KEGG: dka:DKAM_0238 radical SAM domain protein; SPTR: Radical SAM domain protein.
     
 0.848
rps7
SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family.
 
  
 0.840
fusA
Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...]
 
 
 0.831
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
  
  
 0.774
thrS
COGs: COG0441 Threonyl-tRNA synthetase; InterProIPR018158: IPR002320: IPR015011: IPR002314: IPR 004154: IPR006195; KEGG: dka:DKAM_1216 threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain-containing protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; SPTR: Threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); Archaea-specific editing domain of threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA [...]
 
 
 0.773
rpl5
LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
 
  
 0.764
rpoD
DNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
  
  
 0.760
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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