close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV65303.1KEGG: fpl:Ferp_1869 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2276). (315 aa)    
Predicted Functional Partners:
ADV65299.1
CRISPR-associated helicase Cas3; COGs: COG1203 helicase; InterPro IPR006474: IPR001650: IPR014021; KEGG: mfs:MFS40622_1177 CRISPR-associated helicase Cas3; PFAM: helicase domain protein; SMART: helicase domain protein; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: CRISPR-associated helicase Cas3; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3.
 
   
 0.881
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
  
 0.848
ADV65294.1
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
   
 0.847
ADV65292.1
CRISPR-associated protein, Csa1 family; COGs: COG4343 conserved hypothetical protein; InterPro IPR009260; KEGG: kcr:Kcr_0424 CRISPR-associated RAMP Csa1 family protein; PFAM: protein of unknown function DUF911 endonuclease-like; SPTR: CRISPR-associated protein, Csa1 family; TIGRFAM: CRISPR-associated protein, Csa1 family; PFAM: Archaeal protein of unknown function (DUF911); TIGRFAM: CRISPR-associated protein, Csa1 family.
 
   
 0.838
cas2
CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.834
ADV65296.1
CRISPR-associated autoregulator, DevR family; COGs: COG1857 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR002764: IPR010154; KEGG: mfe:Mefer_1436 CRISPR-associated autoregulator, DevR family; SPTR: CRISPR-associated autoregulator, DevR family; TIGRFAM: CRISPR-associated regulatory protein, Csa2 family; CRISPR-associated autoregulator DevR family; PFAM: CRISPR-associated negative autoregulator DevR/Csa2; TIGRFAM: CRISPR-associated autoregulator DevR family; CRISPR-associated regulatory protein, Csa2 family.
 
   
 0.833
ADV65297.1
InterPro IPR010153; KEGG: mfe:Mefer_1435 CRISPR-associated protein Cas5 family; SPTR: CRISPR-associated protein Cas5 family; TIGRFAM: CRISPR-associated protein Cas5 family; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, Apern subtype.
     
 0.814
ADV65301.1
CRISPR locus-related DNA-binding protein; InterPro IPR010163: IPR013383: IPR000835: IPR001845; KEGG: pcl:Pcal_0266 CRISPR-associated Csa3 family protein; PFAM: regulatory protein MarR; SMART: regulatory protein ArsR; SPTR: CRISPR-associated HTH regulatory protein, Csa3 family; TIGRFAM: CRISPR locus-related DNA-binding protein; CRISPR-associated protein DxTHG motif; PFAM: Sugar-specific transcriptional regulator TrmB; TIGRFAM: CRISPR locus-related DNA-binding protein.
     
 0.776
ADV65300.1
Hypothetical protein; KEGG: smr:Smar_0325 CRISPR-associated helicase Cas3 family protein protein; SPTR: CRISPR-associated helicase cas3 domain protein.
       0.767
ADV65295.1
KEGG: pas:Pars_1126 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.759
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.