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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (224 aa)    
Predicted Functional Partners:
ADV65323.1
Protein of unknown function DUF2204; COGs: COG4914 nucleotidyltransferase; InterPro IPR018700; KEGG: dka:DKAM_0863 hypothetical protein; PFAM: Protein of unknown function DUF2204; SPTR: Putative uncharacterized protein; PFAM: Conserved Archaeal protein (DUF2204).
       0.592
ADV64579.1
Cytidyltransferase-related domain protein; COGs: COG0615 Cytidylyltransferase; InterPro IPR004821: IPR007155: IPR004820; KEGG: dka:DKAM_0748 glycerol-3-phosphate cytidylyltransferase; PFAM: protein of unknown function DUF357; cytidylyltransferase; SPTR: Glycerol-3-phosphate cytidylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; PFAM: Cytidylyltransferase; Protein of unknown function (DUF357); TIGRFAM: cytidyltransferase-related domain.
       0.515
psmB
Proteasome endopeptidase complex, beta component; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
       0.475
ADV65324.1
LSU ribosomal protein L40E; InterPro IPR001975; KEGG: dka:DKAM_0862 50S ribosomal protein L40e; PFAM: Ribosomal protein L40e; SPTR: 50S ribosomal protein L40e; PFAM: Ribosomal L40e family; Belongs to the eukaryotic ribosomal protein eL40 family.
       0.445
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
  
   
 0.436
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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