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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV65379.1Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR002478: IPR001678; KEGG: dka:DKAM_1063 RNA (cytosine-C(5)-)-methyltransferase; PFAM: Fmu (Sun) domain protein; PUA domain containing protein; SPTR: RNA (Cytosine-C(5)-)-methyltransferase; PFAM: NOL1/NOP2/sun family; PUA domain. (380 aa)    
Predicted Functional Partners:
ADV64329.1
Ras superfamily GTP-binding protein YlqF; COGs: COG1161 GTPase; InterPro IPR016478: IPR002917; KEGG: dka:DKAM_1385 GTP-binding protein, HSR1-related; PFAM: GTP-binding protein HSR1-related; SPTR: GTP-binding protein, HSR1-related; PFAM: GTPase of unknown function; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
 
 
 0.878
ADV65170.1
COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR012976: IPR002687; KEGG: dka:DKAM_0815 C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; SPTR: Pre-mRNA processing ribonucleoprotein, binding region; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain.
  
 
 0.876
ADV65566.1
Small GTP-binding protein; COGs: COG1084 GTPase; InterPro IPR002917: IPR006073: IPR005225; KEGG: dka:DKAM_1284 small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; SPTR: Small GTP-binding protein; TIGRFAM: small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
  
 
 0.871
ADV64644.1
KEGG: dka:DKAM_0585 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family (UPF0113).
  
 
 0.857
rpl7ae
LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
 
 
 0.800
rps8e
COGs: COG2007 Ribosomal protein S8E; InterPro IPR018283: IPR020919: IPR001047; KEGG: dka:DKAM_0926 30S ribosomal protein S8e; SPTR: 30S ribosomal protein S8e; TIGRFAM: ribosomal protein S8e; PFAM: Ribosomal protein S8e; TIGRFAM: ribosomal protein S8.e.
   
 
 0.798
rpl10
LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
  
 
 0.797
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.794
ADV65606.1
Brix domain protein; Probably involved in the biogenesis of the ribosome.
 
 
 0.794
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 
 0.768
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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