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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisSCOGs: COG0124 Histidyl-tRNA synthetase; InterProIPR015807: IPR004516: IPR002314: IPR004154: IPR 006195; KEGG: dka:DKAM_1211 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (434 aa)    
Predicted Functional Partners:
ADV64368.1
COGs: COG1093 Translation initiation factor 2 alpha subunit (eIF-2alpha); InterPro IPR003029: IPR011488; KEGG: dka:DKAM_1424 translation initiation factor IF-2 subunit alpha; PFAM: translation initiation factor 2, alpha subunit; RNA binding S1 domain protein; SPTR: Translation initiation factor IF-2 subunit alpha; PFAM: Eukaryotic translation initiation factor 2 alpha subunit; S1 RNA binding domain.
   
 0.911
ADV65496.1
InterPro IPR006678: IPR006677; KEGG: dka:DKAM_1212 tRNA intron endonuclease, catalytic-like protein; PFAM: tRNA intron endonuclease, catalytic domain-containing protein; tRNA intron endonuclease domain-containing protein; SPTR: tRNA intron endonuclease, catalytic-like protein; PFAM: tRNA intron endonuclease, catalytic C-terminal domain.
       0.882
thrS
COGs: COG0441 Threonyl-tRNA synthetase; InterProIPR018158: IPR002320: IPR015011: IPR002314: IPR 004154: IPR006195; KEGG: dka:DKAM_1216 threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain-containing protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; SPTR: Threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); Archaea-specific editing domain of threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA [...]
 
 
 0.853
ADV64876.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR017926: IPR006220: IPR011702: IPR004739: IPR 001674: IPR000991; KEGG: dka:DKAM_0479 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
  
  
 0.832
ADV65633.1
COGs: COG5257 Translation initiation factor 2 gamma subunit (eIF-2gamma; GTPase); InterPro IPR000795: IPR015256: IPR005225; KEGG: dka:DKAM_1347 translation initiation factor IF-2 subunit gamma; PFAM: protein synthesis factor GTP-binding; Initiation factor eIF2 gamma domain protein; SPTR: Translation initiation factor IF-2 subunit gamma; TIGRFAM: small GTP-binding protein; PFAM: Elongation factor Tu GTP binding domain; Initiation factor eIF2 gamma, C terminal; TIGRFAM: small GTP-binding protein domain; translation elongation factor TU; translation initiation factor 2 subunit gamma.
  
 0.779
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
 
 0.770
cysS
COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR002308: IPR015803: IPR015273; KEGG: dka:DKAM_0804 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase.
 
  
 0.744
ADV65495.1
Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
  
    0.720
ADV64538.1
COGs: COG2872 metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain; InterPro IPR018165: IPR018164: IPR012947; KEGG: dka:DKAM_0059 threonyl/alanyl tRNA synthetase; PFAM: Threonyl/alanyl tRNA synthetase SAD; Alanyl-tRNA synthetase, class IIc-like; SPTR: Threonyl/alanyl tRNA synthetase; PFAM: Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetases class II (A).
  
 
 0.719
rtcB
Protein of unknown function UPF0027; COGs: COG1690 conserved hypothetical protein; InterPro IPR001233; KEGG: dka:DKAM_1210 protein of unknown function UPF0027; PFAM: protein of unknown function UPF0027; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein family UPF0027; Belongs to the RtcB family.
  
  
 0.713
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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