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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtcBProtein of unknown function UPF0027; COGs: COG1690 conserved hypothetical protein; InterPro IPR001233; KEGG: dka:DKAM_1210 protein of unknown function UPF0027; PFAM: protein of unknown function UPF0027; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein family UPF0027; Belongs to the RtcB family. (482 aa)    
Predicted Functional Partners:
ADV65440.1
Archease family protein; COGs: COG1371 conserved hypothetical protein; InterPro IPR002804; KEGG: dka:DKAM_1139 DUF101 domain containing protein; PFAM: protein of unknown function DUF101; SPTR: DUF101 domain containing protein; PFAM: Archease protein family (DUF101/UPF0211).
 
 0.924
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
  
 0.812
hisS
COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR015807: IPR004516: IPR002314: IPR004154: IPR 006195; KEGG: dka:DKAM_1211 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.713
ADV65496.1
InterPro IPR006678: IPR006677; KEGG: dka:DKAM_1212 tRNA intron endonuclease, catalytic-like protein; PFAM: tRNA intron endonuclease, catalytic domain-containing protein; tRNA intron endonuclease domain-containing protein; SPTR: tRNA intron endonuclease, catalytic-like protein; PFAM: tRNA intron endonuclease, catalytic C-terminal domain.
     
 0.686
prf1
Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.655
top6A
DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
  
    0.576
top6B
DNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
       0.562
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
   
 0.532
ADV64368.1
COGs: COG1093 Translation initiation factor 2 alpha subunit (eIF-2alpha); InterPro IPR003029: IPR011488; KEGG: dka:DKAM_1424 translation initiation factor IF-2 subunit alpha; PFAM: translation initiation factor 2, alpha subunit; RNA binding S1 domain protein; SPTR: Translation initiation factor IF-2 subunit alpha; PFAM: Eukaryotic translation initiation factor 2 alpha subunit; S1 RNA binding domain.
   
  
 0.430
ADV65495.1
Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
       0.424
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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