Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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rtcBProtein of unknown function UPF0027; COGs: COG1690 conserved hypothetical protein; InterPro IPR001233; KEGG: dka:DKAM_1210 protein of unknown function UPF0027; PFAM: protein of unknown function UPF0027; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein family UPF0027; Belongs to the RtcB family. (482 aa)    
Predicted Functional Partners:
ADV65440.1
Archease family protein; COGs: COG1371 conserved hypothetical protein; InterPro IPR002804; KEGG: dka:DKAM_1139 DUF101 domain containing protein; PFAM: protein of unknown function DUF101; SPTR: DUF101 domain containing protein; PFAM: Archease protein family (DUF101/UPF0211).
 
 0.976
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
  
 0.901
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
   
 0.765
ADV65496.1
InterPro IPR006678: IPR006677; KEGG: dka:DKAM_1212 tRNA intron endonuclease, catalytic-like protein; PFAM: tRNA intron endonuclease, catalytic domain-containing protein; tRNA intron endonuclease domain-containing protein; SPTR: tRNA intron endonuclease, catalytic-like protein; PFAM: tRNA intron endonuclease, catalytic C-terminal domain.
     
 0.746
hisS
COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR015807: IPR004516: IPR002314: IPR004154: IPR 006195; KEGG: dka:DKAM_1211 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.675
prf1
Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
  
 0.672
ADV64551.1
COGs: COG1676 tRNA splicing endonuclease; InterPro IPR016442: IPR006676: IPR006678: IPR006677; KEGG: shc:Shell_1338 tRNA intron endonuclease; PFAM: tRNA intron endonuclease, catalytic domain-containing protein; tRNA intron endonuclease domain-containing protein; SPTR: tRNA intron endonuclease; TIGRFAM: tRNA intron endonuclease; PFAM: tRNA intron endonuclease, catalytic C-terminal domain; tRNA intron endonuclease, N-terminal domain; TIGRFAM: tRNA intron endonuclease.
     
 0.669
rnz
RNAse Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
     
 0.667
ADV64429.1
InterPro IPR006021; KEGG: dka:DKAM_0961 nuclease (SNase domain protein); PFAM: nuclease (SNase domain-containing protein); SMART: nuclease (SNase domain-containing protein); SPTR: Nuclease (SNase domain protein); PFAM: Staphylococcal nuclease homologue.
     
 0.663
eif1a
Translation initiation factor 1A (aeIF-1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
     
 0.657
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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