Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thrSCOGs: COG0441 Threonyl-tRNA synthetase; InterProIPR018158: IPR002320: IPR015011: IPR002314: IPR 004154: IPR006195; KEGG: dka:DKAM_1216 threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain-containing protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; SPTR: Threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); Archaea-specific editing domain of threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA [...] (611 aa)    
Predicted Functional Partners:
hisS
COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR015807: IPR004516: IPR002314: IPR004154: IPR 006195; KEGG: dka:DKAM_1211 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 
 0.934
ADV64824.1
COGs: COG0495 Leucyl-tRNA synthetase; InterProIPR001412: IPR004493: IPR015413: IPR020754: IPR 013155; KEGG: dka:DKAM_0624 leucyl-tRNA synthetase; PFAM: tRNA synthetase valyl/leucyl anticodon-binding; tRNA synthetase class I (M); Lysyl-tRNA synthetase, class Ic; SPTR: Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, archaeal and cytosolic family; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.920
ADV65367.1
COGs: COG0525 Valyl-tRNA synthetase; InterPro IPR019754: IPR002300: IPR013155: IPR004039; KEGG: dka:DKAM_1053 valyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ia; tRNA synthetase valyl/leucyl anticodon-binding; SPTR: Valyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain.
 
 
 0.914
ADV64905.1
COGs: COG0143 Methionyl-tRNA synthetase; InterPro IPR014758: IPR001412: IPR002304: IPR015413; KEGG: dka:DKAM_0547 methionyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); SPTR: Methionyl-tRNA synthetase; TIGRFAM: methionyl-tRNA synthetase; PFAM: Anticodon-binding domain; tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.904
ADV64923.1
Arginine--tRNA ligase; COGs: COG0018 Arginyl-tRNA synthetase; InterPro IPR015945: IPR008909; KEGG: dka:DKAM_0500 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; SPTR: Arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; tRNA synthetases class I (R); Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.889
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
  
 
 0.851
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
 
 
 0.837
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
 
 0.812
ADV64876.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR017926: IPR006220: IPR011702: IPR004739: IPR 001674: IPR000991; KEGG: dka:DKAM_0479 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
  
  
 0.808
ADV65267.1
COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterPro IPR004529: IPR002319: IPR006195; KEGG: dka:DKAM_0237 phenylalanyl-tRNA synthetase subunit alpha; PFAM: phenylalanyl-tRNA synthetase class IIc; SPTR: PheS; phenylalanyl-tRNA synthetase subunit alpha; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit.
 
 
 0.803
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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