STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADV65533.1COGs: COG0469 Pyruvate kinase; InterPro IPR015793: IPR001697; KEGG: dka:DKAM_1243 pyruvate kinase; PFAM: Pyruvate kinase barrel; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (469 aa)    
Predicted Functional Partners:
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 0.994
ADV64387.1
Bifunctional phosphoglucose/phosphomannose isomerase; COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR011857: IPR019490; KEGG: dka:DKAM_1010 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like; PRIAM: Mannose-6-phosphate isomerase; SPTR: Bifunctional phosphoglucose/phosphomannose isomerase; TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bacterial phospho-glucose isomerase C-terminal region; SIS domain; TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase.
  
 0.985
ADV64816.1
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
    
 0.965
pgk
COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576: IPR015911; KEGG: dka:DKAM_0184 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
 
 0.939
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
  
 
 0.938
fbp
Fructose-bisphosphate aldolase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
 0.930
ADV64638.1
2-oxoglutarate ferredoxin oxidoreductase, beta subunit; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: dka:DKAM_0534 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
  
 0.921
ADV64651.1
Thiamine pyrophosphate TPP-binding domain-containing protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: dka:DKAM_0578 pyruvate synthase subunit PorB; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Pyruvate synthase subunit porB; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
  
 0.921
ADV65489.1
Thiamine pyrophosphate TPP-binding domain-containing protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: dka:DKAM_1188 pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
  
 0.921
ADV65032.1
Conserved carboxylase region; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000891: IPR003379; KEGG: dka:DKAM_0467 pyruvate/oxaloacetate carboxyltransferase; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; SPTR: Pyruvate/oxaloacetate carboxyltransferase; PFAM: HMGL-like; Conserved carboxylase domain.
  
 
 0.920
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.