| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OSCT_0743 | OSCT_0837 | OSCT_0743 | OSCT_0837 | Aspartate kinase; Belongs to the aspartokinase family. | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | 0.870 |
| OSCT_0743 | OSCT_1537 | OSCT_0743 | OSCT_1537 | Aspartate kinase; Belongs to the aspartokinase family. | Homoserine dehydrogenase. | 0.998 |
| OSCT_0743 | OSCT_1593 | OSCT_0743 | OSCT_1593 | Aspartate kinase; Belongs to the aspartokinase family. | Threonine dehydratase. | 0.893 |
| OSCT_0743 | OSCT_1842 | OSCT_0743 | OSCT_1842 | Aspartate kinase; Belongs to the aspartokinase family. | O-acetylhomoserine/O-acetylserine sulfhydrylase. | 0.481 |
| OSCT_0743 | OSCT_2159 | OSCT_0743 | OSCT_2159 | Aspartate kinase; Belongs to the aspartokinase family. | O-acetylhomoserine/O-acetylserine sulfhydrylase. | 0.481 |
| OSCT_0743 | OSCT_2365 | OSCT_0743 | OSCT_2365 | Aspartate kinase; Belongs to the aspartokinase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.944 |
| OSCT_0743 | OSCT_2601 | OSCT_0743 | OSCT_2601 | Aspartate kinase; Belongs to the aspartokinase family. | Cystathionine gamma-synthase. | 0.627 |
| OSCT_0743 | glyA | OSCT_0743 | OSCT_0612 | Aspartate kinase; Belongs to the aspartokinase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.600 |
| OSCT_0743 | metXA | OSCT_0743 | OSCT_1841 | Aspartate kinase; Belongs to the aspartokinase family. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.958 |
| OSCT_0743 | trpB | OSCT_0743 | OSCT_0363 | Aspartate kinase; Belongs to the aspartokinase family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.607 |
| OSCT_0837 | OSCT_0743 | OSCT_0837 | OSCT_0743 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Aspartate kinase; Belongs to the aspartokinase family. | 0.870 |
| OSCT_0837 | OSCT_1537 | OSCT_0837 | OSCT_1537 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Homoserine dehydrogenase. | 0.912 |
| OSCT_0837 | OSCT_1593 | OSCT_0837 | OSCT_1593 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Threonine dehydratase. | 0.866 |
| OSCT_0837 | OSCT_2365 | OSCT_0837 | OSCT_2365 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.914 |
| OSCT_0837 | OSCT_2601 | OSCT_0837 | OSCT_2601 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Cystathionine gamma-synthase. | 0.459 |
| OSCT_0837 | glyA | OSCT_0837 | OSCT_0612 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
| OSCT_0837 | metXA | OSCT_0837 | OSCT_1841 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.854 |
| OSCT_0837 | trpB | OSCT_0837 | OSCT_0363 | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.902 |
| OSCT_1537 | OSCT_0743 | OSCT_1537 | OSCT_0743 | Homoserine dehydrogenase. | Aspartate kinase; Belongs to the aspartokinase family. | 0.998 |
| OSCT_1537 | OSCT_0837 | OSCT_1537 | OSCT_0837 | Homoserine dehydrogenase. | Phosphoserine phosphatase SerB:HAD-superfamily hydrolase, subfamily IB (PSPase-like). | 0.912 |