| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OSCT_0893 | OSCT_2154 | OSCT_0893 | OSCT_2154 | Thymidylate synthase. | C_GCAxxG_C_C family protein. | 0.939 |
| OSCT_0893 | OSCT_2365 | OSCT_0893 | OSCT_2365 | Thymidylate synthase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.619 |
| OSCT_0893 | fmt | OSCT_0893 | OSCT_1733 | Thymidylate synthase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.612 |
| OSCT_0893 | glyA | OSCT_0893 | OSCT_0612 | Thymidylate synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.823 |
| OSCT_2153 | OSCT_2154 | OSCT_2153 | OSCT_2154 | Hypothetical protein. | C_GCAxxG_C_C family protein. | 0.586 |
| OSCT_2154 | OSCT_0893 | OSCT_2154 | OSCT_0893 | C_GCAxxG_C_C family protein. | Thymidylate synthase. | 0.939 |
| OSCT_2154 | OSCT_2153 | OSCT_2154 | OSCT_2153 | C_GCAxxG_C_C family protein. | Hypothetical protein. | 0.586 |
| OSCT_2154 | OSCT_2155 | OSCT_2154 | OSCT_2155 | C_GCAxxG_C_C family protein. | Hypothetical protein. | 0.579 |
| OSCT_2154 | OSCT_2365 | OSCT_2154 | OSCT_2365 | C_GCAxxG_C_C family protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.901 |
| OSCT_2154 | clpP | OSCT_2154 | OSCT_0671 | C_GCAxxG_C_C family protein. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.705 |
| OSCT_2154 | clpP-2 | OSCT_2154 | OSCT_1642 | C_GCAxxG_C_C family protein. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.705 |
| OSCT_2154 | clpX | OSCT_2154 | OSCT_0670 | C_GCAxxG_C_C family protein. | Sigma 54 interacting domain protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.842 |
| OSCT_2154 | fmt | OSCT_2154 | OSCT_1733 | C_GCAxxG_C_C family protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.604 |
| OSCT_2154 | glyA | OSCT_2154 | OSCT_0612 | C_GCAxxG_C_C family protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.641 |
| OSCT_2154 | pheT | OSCT_2154 | OSCT_2990 | C_GCAxxG_C_C family protein. | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.612 |
| OSCT_2155 | OSCT_2154 | OSCT_2155 | OSCT_2154 | Hypothetical protein. | C_GCAxxG_C_C family protein. | 0.579 |
| OSCT_2365 | OSCT_0893 | OSCT_2365 | OSCT_0893 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase. | 0.619 |
| OSCT_2365 | OSCT_2154 | OSCT_2365 | OSCT_2154 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | C_GCAxxG_C_C family protein. | 0.901 |
| OSCT_2365 | fmt | OSCT_2365 | OSCT_1733 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.877 |
| OSCT_2365 | glyA | OSCT_2365 | OSCT_0612 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.911 |