lexA protein (Oscillochloris trichoides) - STRING interaction network

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lexA

SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (215 aa)

Predicted Functional Partners:

recA

0.984

OSCT_3182

0.845

OSCT_0782

0.736

OSCT_1438

0.719

dinG

0.644

recO

0.554

OSCT_1679

0.528

recX

0.522

OSCT_2673

0.513

OSCT_2331

0.512

Your Current Organism:

Oscillochloris trichoides

NCBI taxonomy Id: 765420
Other names: O. trichoides DG-6, Oscillochloris trichoides DG-6, Oscillochloris trichoides str. DG-6, Oscillochloris trichoides strain DG-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OSCT_0782	lexA	OSCT_0782	OSCT_2330	DNA methylase N-4/N-6 domain protein; Belongs to the N(4)/N(6)-methyltransferase family.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.736
OSCT_1438	dinG	OSCT_1438	OSCT_0738	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	0.483
OSCT_1438	lexA	OSCT_1438	OSCT_2330	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.719
OSCT_1438	recA	OSCT_1438	OSCT_1049	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.718
OSCT_1438	recX	OSCT_1438	OSCT_1050	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.	0.517
OSCT_1679	dinG	OSCT_1679	OSCT_0738	DNA polymerase III, epsilon subunit.	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	0.881
OSCT_1679	lexA	OSCT_1679	OSCT_2330	DNA polymerase III, epsilon subunit.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.528
OSCT_1679	recA	OSCT_1679	OSCT_1049	DNA polymerase III, epsilon subunit.	recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.424
OSCT_2331	lexA	OSCT_2331	OSCT_2330	Transcriptional regulator protein.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.512
OSCT_2673	lexA	OSCT_2673	OSCT_2330	Helix-turn-helix domain-containing protein.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.513
OSCT_2673	recA	OSCT_2673	OSCT_1049	Helix-turn-helix domain-containing protein.	recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.525
OSCT_2673	recX	OSCT_2673	OSCT_1050	Helix-turn-helix domain-containing protein.	Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.	0.423
OSCT_3182	lexA	OSCT_3182	OSCT_2330	DNA methylase N-4/N-6 domain-containing protein; Belongs to the N(4)/N(6)-methyltransferase family.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.845
dinG	OSCT_1438	OSCT_0738	OSCT_1438	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	0.483
dinG	OSCT_1679	OSCT_0738	OSCT_1679	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	DNA polymerase III, epsilon subunit.	0.881
dinG	lexA	OSCT_0738	OSCT_2330	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.644
dinG	recA	OSCT_0738	OSCT_1049	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.699
dinG	recO	OSCT_0738	OSCT_1251	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.576
dinG	recX	OSCT_0738	OSCT_1050	DNA polymerase III, epsilon subunit; 3'-5' exonuclease.	Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.	0.533
lexA	OSCT_0782	OSCT_2330	OSCT_0782	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	DNA methylase N-4/N-6 domain protein; Belongs to the N(4)/N(6)-methyltransferase family.	0.736

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