| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OSCT_1359 | OSCT_1360 | OSCT_1359 | OSCT_1360 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.999 |
| OSCT_1359 | OSCT_1361 | OSCT_1359 | OSCT_1361 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.968 |
| OSCT_1359 | OSCT_1800 | OSCT_1359 | OSCT_1800 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen III synthase HEM4. | 0.583 |
| OSCT_1359 | OSCT_2402 | OSCT_1359 | OSCT_2402 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.997 |
| OSCT_1359 | OSCT_2403 | OSCT_1359 | OSCT_2403 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | precorrin-3B C17-methyltransferase. | 0.976 |
| OSCT_1359 | OSCT_2404 | OSCT_1359 | OSCT_2404 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.882 |
| OSCT_1359 | OSCT_2408 | OSCT_1359 | OSCT_2408 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin (vitamin B12) biosynthesis CbiX protein. | 0.943 |
| OSCT_1359 | cbiA | OSCT_1359 | OSCT_2400 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.549 |
| OSCT_1359 | hemA | OSCT_1359 | OSCT_1357 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.967 |
| OSCT_1359 | hemC | OSCT_1359 | OSCT_1358 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
| OSCT_1360 | OSCT_1359 | OSCT_1360 | OSCT_1359 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.999 |
| OSCT_1360 | OSCT_1361 | OSCT_1360 | OSCT_1361 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.825 |
| OSCT_1360 | OSCT_1800 | OSCT_1360 | OSCT_1800 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4. | 0.916 |
| OSCT_1360 | OSCT_2402 | OSCT_1360 | OSCT_2402 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.900 |
| OSCT_1360 | OSCT_2403 | OSCT_1360 | OSCT_2403 | Porphobilinogen synthase; Belongs to the ALAD family. | precorrin-3B C17-methyltransferase. | 0.654 |
| OSCT_1360 | hemA | OSCT_1360 | OSCT_1357 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.936 |
| OSCT_1360 | hemC | OSCT_1360 | OSCT_1358 | Porphobilinogen synthase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
| OSCT_1361 | OSCT_1359 | OSCT_1361 | OSCT_1359 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.968 |
| OSCT_1361 | OSCT_1360 | OSCT_1361 | OSCT_1360 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.825 |
| OSCT_1361 | OSCT_2402 | OSCT_1361 | OSCT_2402 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.915 |