| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OSCT_1359 | OSCT_2402 | OSCT_1359 | OSCT_2402 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.994 |
| OSCT_1359 | OSCT_2403 | OSCT_1359 | OSCT_2403 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | precorrin-3B C17-methyltransferase. | 0.956 |
| OSCT_1359 | OSCT_2404 | OSCT_1359 | OSCT_2404 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.893 |
| OSCT_1359 | OSCT_2405 | OSCT_1359 | OSCT_2405 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | 0.672 |
| OSCT_1359 | OSCT_2407 | OSCT_1359 | OSCT_2407 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-8X methylmutase CbiC/CobH. | 0.527 |
| OSCT_1359 | OSCT_2408 | OSCT_1359 | OSCT_2408 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin (vitamin B12) biosynthesis CbiX protein. | 0.957 |
| OSCT_1359 | cbiA | OSCT_1359 | OSCT_2400 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.554 |
| OSCT_1359 | cbiD | OSCT_1359 | OSCT_2406 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.569 |
| OSCT_1359 | cobQ | OSCT_1359 | OSCT_2396 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.549 |
| OSCT_1359 | cobS | OSCT_1359 | OSCT_2399 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.541 |
| OSCT_2402 | OSCT_1359 | OSCT_2402 | OSCT_1359 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.994 |
| OSCT_2402 | OSCT_2403 | OSCT_2402 | OSCT_2403 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | precorrin-3B C17-methyltransferase. | 0.987 |
| OSCT_2402 | OSCT_2404 | OSCT_2402 | OSCT_2404 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.983 |
| OSCT_2402 | OSCT_2405 | OSCT_2402 | OSCT_2405 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | 0.604 |
| OSCT_2402 | OSCT_2408 | OSCT_2402 | OSCT_2408 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin (vitamin B12) biosynthesis CbiX protein. | 0.969 |
| OSCT_2402 | cbiA | OSCT_2402 | OSCT_2400 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.889 |
| OSCT_2402 | cobQ | OSCT_2402 | OSCT_2396 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.551 |
| OSCT_2402 | cobS | OSCT_2402 | OSCT_2399 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.546 |
| OSCT_2403 | OSCT_1359 | OSCT_2403 | OSCT_1359 | precorrin-3B C17-methyltransferase. | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.956 |
| OSCT_2403 | OSCT_2402 | OSCT_2403 | OSCT_2402 | precorrin-3B C17-methyltransferase. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.987 |