STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
A0A178DS79Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2969 aa)    
Predicted Functional Partners:
A0A178DJD4
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
0.997
A0A178E537
HRDC domain-containing protein.
   
 0.995
A0A178EBU4
Ribonuclease H-like protein.
   
 0.995
A0A178E467
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.989
A0A178EDN8
DNA repair protein rad50.
   
 0.986
A0A178DL30
TPR-like protein.
    
 0.985
A0A178DQR3
BRCT domain-containing protein.
    
 0.980
A0A178EAH9
Uncharacterized protein.
     
 0.978
A0A178E239
DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.
    
 0.960
A0A178DXP9
ATP-dependent DNA helicase II subunit 1.
    
 0.954
Your Current Organism:
Pyrenochaeta sp. DS3sAY3a
NCBI taxonomy Id: 765867
Other names: P. sp. DS3sAY3a
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.