Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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A0A178AA85DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (616 aa)    
Predicted Functional Partners:
A0A178AFF4
DUF1767 domain-containing protein.
    
 0.999
A0A178A9T0
UvrD-helicase-domain-containing protein.
   
 0.997
A0A178B3X4
HRDC domain-containing protein.
  
 0.997
A0A178BBS2
3'-5' exonuclease domain-containing protein.
  
 0.997
A0A178AVB8
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
    
 0.990
A0A178AN57
DNA repair protein.
    
 0.988
A0A178ABZ4
Uncharacterized protein.
  
 0.985
A0A178AQ92
Replication protein A, subunit RPA32.
    
 0.981
A0A178BD44
P-loop containing nucleoside triphosphate hydrolase protein.
    
 0.980
A0A178A6W9
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.979
Your Current Organism:
Stagonospora sp. SRC1lsM3a
NCBI taxonomy Id: 765868
Other names: S. sp. SRC1lsM3a
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