| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A0A178A9T0 | A0A178AA85 | A0A178A9T0 | A0A178AA85 | UvrD-helicase-domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.997 |
| A0A178A9T0 | A0A178ABZ4 | A0A178A9T0 | A0A178ABZ4 | UvrD-helicase-domain-containing protein. | Uncharacterized protein. | 0.931 |
| A0A178A9T0 | A0A178AFF4 | A0A178A9T0 | A0A178AFF4 | UvrD-helicase-domain-containing protein. | DUF1767 domain-containing protein. | 0.985 |
| A0A178A9T0 | A0A178AN57 | A0A178A9T0 | A0A178AN57 | UvrD-helicase-domain-containing protein. | DNA repair protein. | 0.916 |
| A0A178A9T0 | A0A178AVB8 | A0A178A9T0 | A0A178AVB8 | UvrD-helicase-domain-containing protein. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.959 |
| A0A178A9T0 | A0A178B1F4 | A0A178A9T0 | A0A178B1F4 | UvrD-helicase-domain-containing protein. | P-loop containing nucleoside triphosphate hydrolase protein. | 0.967 |
| A0A178A9T0 | A0A178B3X4 | A0A178A9T0 | A0A178B3X4 | UvrD-helicase-domain-containing protein. | HRDC domain-containing protein. | 0.908 |
| A0A178A9T0 | A0A178BBS2 | A0A178A9T0 | A0A178BBS2 | UvrD-helicase-domain-containing protein. | 3'-5' exonuclease domain-containing protein. | 0.908 |
| A0A178A9T0 | A0A178BD44 | A0A178A9T0 | A0A178BD44 | UvrD-helicase-domain-containing protein. | P-loop containing nucleoside triphosphate hydrolase protein. | 0.982 |
| A0A178A9T0 | SLX1 | A0A178A9T0 | A0A178B4B1 | UvrD-helicase-domain-containing protein. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.535 |
| A0A178AA85 | A0A178A9T0 | A0A178AA85 | A0A178A9T0 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | UvrD-helicase-domain-containing protein. | 0.997 |
| A0A178AA85 | A0A178ABZ4 | A0A178AA85 | A0A178ABZ4 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Uncharacterized protein. | 0.985 |
| A0A178AA85 | A0A178AFF4 | A0A178AA85 | A0A178AFF4 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DUF1767 domain-containing protein. | 0.999 |
| A0A178AA85 | A0A178AN57 | A0A178AA85 | A0A178AN57 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA repair protein. | 0.988 |
| A0A178AA85 | A0A178AVB8 | A0A178AA85 | A0A178AVB8 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.990 |
| A0A178AA85 | A0A178B1F4 | A0A178AA85 | A0A178B1F4 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | P-loop containing nucleoside triphosphate hydrolase protein. | 0.978 |
| A0A178AA85 | A0A178B3X4 | A0A178AA85 | A0A178B3X4 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | HRDC domain-containing protein. | 0.997 |
| A0A178AA85 | A0A178BBS2 | A0A178AA85 | A0A178BBS2 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 3'-5' exonuclease domain-containing protein. | 0.997 |
| A0A178AA85 | A0A178BD44 | A0A178AA85 | A0A178BD44 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | P-loop containing nucleoside triphosphate hydrolase protein. | 0.980 |
| A0A178AA85 | SLX1 | A0A178AA85 | A0A178B4B1 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.959 |
