AHF02892.1 protein (Marichromatium purpuratum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AHF02892.1

Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)

Predicted Functional Partners:

AHF02893.1

0.958

AHF05465.1

0.927

AHF02891.1

0.926

AHF03546.1

0.917

AHF03852.1

0.908

AHF03623.1

0.907

AHF05533.1

0.894

AHF05568.1

0.885

AHF04612.1

0.882

AHF03972.1

0.880

Your Current Organism:

Marichromatium purpuratum

NCBI taxonomy Id: 765910
Other names: M. purpuratum 984, Marichromatium purpuratum 984, Marichromatium purpuratum str. 984, Marichromatium purpuratum strain 984

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHF02891.1	AHF02892.1	MARPU_02665	MARPU_02670	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.926
AHF02891.1	AHF02893.1	MARPU_02665	MARPU_02675	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
AHF02891.1	AHF03546.1	MARPU_02665	MARPU_06455	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AHF02891.1	AHF03623.1	MARPU_02665	MARPU_06905	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AHF02891.1	AHF03852.1	MARPU_02665	MARPU_08200	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AHF02891.1	AHF03972.1	MARPU_02665	MARPU_08935	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AHF02891.1	AHF04612.1	MARPU_02665	MARPU_12740	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
AHF02891.1	AHF05465.1	MARPU_02665	MARPU_07530	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
AHF02891.1	AHF05533.1	MARPU_02665	MARPU_10240	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
AHF02891.1	AHF05568.1	MARPU_02665	MARPU_11865	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.997
AHF02892.1	AHF02891.1	MARPU_02670	MARPU_02665	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.926
AHF02892.1	AHF02893.1	MARPU_02670	MARPU_02675	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.958
AHF02892.1	AHF03546.1	MARPU_02670	MARPU_06455	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.917
AHF02892.1	AHF03623.1	MARPU_02670	MARPU_06905	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.907
AHF02892.1	AHF03852.1	MARPU_02670	MARPU_08200	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.908
AHF02892.1	AHF03972.1	MARPU_02670	MARPU_08935	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.880
AHF02892.1	AHF04612.1	MARPU_02670	MARPU_12740	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.882
AHF02892.1	AHF05465.1	MARPU_02670	MARPU_07530	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.927
AHF02892.1	AHF05533.1	MARPU_02670	MARPU_10240	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.894
AHF02892.1	AHF05568.1	MARPU_02670	MARPU_11865	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.885

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.846

expected number of edges:

16

PPI enrichment p-value:

1.71e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042537

Benzene-containing compound metabolic process

8 of 12

2.82

8.69

1.34e-17

GO:0006569

Tryptophan catabolic process

7 of 7

2.99

8.13

4.93e-16

GO:0034354

De novo NAD biosynthetic process from tryptophan

7 of 9

2.88

8.02

4.93e-16

GO:0043420

Anthranilate metabolic process

5 of 5

2.99

5.9

1.09e-11

GO:0019805

Quinolinate biosynthetic process

5 of 5

2.99

5.9

1.09e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004502

Kynurenine 3-monooxygenase activity

3 of 3

2.99

2.56

2.21e-05

GO:0016702

Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

3 of 12

2.39

2.0

0.00017

GO:0033754

Indoleamine 2,3-dioxygenase activity

2 of 2

2.99

1.6

0.0013

GO:0003882

CDP-diacylglycerol-serine O-phosphatidyltransferase activity

2 of 3

2.82

1.55

0.0015

GO:0071949

FAD binding

3 of 37

1.9

1.44

0.0013

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005741

Mitochondrial outer membrane

3 of 49

1.78

0.97

0.0123

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9771

Mixed, incl. Lipid biosynthetic process, and Tryptophan catabolism

10 of 172

1.76

4.28

2.15e-14

CL:9973

Amine catabolic process

4 of 5

2.9

4.11

2.57e-08

CL:9773

Mixed, incl. Steroid biosynthetic process, and Tryptophan catabolism

8 of 108

1.86

4.06

1.55e-11

CL:10041

Phosphatidylserine metabolic process, and Synthesis of CL

2 of 7

2.45

1.13

0.0085

CL:9779

Steroid biosynthetic process, and Tryptophan catabolism

3 of 60

1.69

1.02

0.0085

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00380

Tryptophan metabolism

8 of 42

2.27

6.48

2.63e-15

map01100

Metabolic pathways

11 of 1981

0.74

0.73

5.59e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71240

Tryptophan catabolism

11 of 24

2.65

11.89

6.26e-26

MAP-71291

Metabolism of amino acids and derivatives

11 of 236

1.66

4.1

3.13e-16

MAP-1430728

Metabolism

11 of 1327

0.91

1.04

2.96e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005741

Mitochondrial outer membrane

3 of 64

1.66

0.89

0.0161

GOCC:0005737

Cytoplasm

11 of 2575

0.62

0.54

0.00013

GOCC:0005739

Mitochondrion

5 of 623

0.9

0.49

0.0398

GOCC:0031090

Organelle membrane

5 of 695

0.85

0.46

0.0473

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0662

Pyridine nucleotide biosynthesis

3 of 5

2.77

2.88

4.80e-06

KW-0223

Dioxygenase

3 of 12

2.39

2.41

2.59e-05

KW-0560

Oxidoreductase

6 of 145

1.61

2.31

6.39e-07

KW-1000

Mitochondrion outer membrane

2 of 5

2.6

1.67

0.00087

KW-0503

Monooxygenase

3 of 37

1.9

1.66

0.00042

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01494

FAD binding domain

3 of 4

2.87

2.49

2.85e-05

PF01231

Indoleamine 2,3-dioxygenase

2 of 3

2.82

1.27

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002938

FAD-binding domain

3 of 4

2.87

2.24

8.17e-05

IPR037217

Tryptophan/Indoleamine 2,3-dioxygenase-like

2 of 3

2.82

1.15

0.0084

IPR027545

Kynurenine 3-monooxygenase

2 of 2

2.99

1.15

0.0084

IPR000898

Indoleamine 2,3-dioxygenase

2 of 3

2.82

1.15

0.0084

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 34

1.94

1.07

0.0084

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