AFL72633.1 protein (Thiocystis violascens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AFL72633.1

PFAM: Siphovirus Gp157. (166 aa)

Predicted Functional Partners:

AFL72632.1

0.712

AFL72634.1

0.637

AFL72513.1

0.619

AFL72534.1

0.619

AFL72773.1

0.619

AFL72775.1

0.619

AFL74573.1

0.619

AFL74585.1

0.619

AFL74799.1

0.619

AFL74836.1

0.619

Your Current Organism:

Thiocystis violascens

NCBI taxonomy Id: 765911
Other names: T. violascens DSM 198, Thiocystis violascens DSM 198, Thiocystis violascens str. DSM 198, Thiocystis violascens strain DSM 198

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFL72513.1	AFL72633.1	Thivi_0446	Thivi_0575	Hypothetical protein.	PFAM: Siphovirus Gp157.	0.619
AFL72534.1	AFL72633.1	Thivi_0473	Thivi_0575	Hypothetical protein.	PFAM: Siphovirus Gp157.	0.619
AFL72632.1	AFL72633.1	Thivi_0574	Thivi_0575	Hypothetical protein.	PFAM: Siphovirus Gp157.	0.712
AFL72632.1	AFL72634.1	Thivi_0574	Thivi_0576	Hypothetical protein.	ATPase family protein associated with various cellular activities (AAA); PFAM: AAA domain (dynein-related subfamily); CbbQ/NirQ/NorQ C-terminal.	0.429
AFL72633.1	AFL72513.1	Thivi_0575	Thivi_0446	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72633.1	AFL72534.1	Thivi_0575	Thivi_0473	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72633.1	AFL72632.1	Thivi_0575	Thivi_0574	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.712
AFL72633.1	AFL72634.1	Thivi_0575	Thivi_0576	PFAM: Siphovirus Gp157.	ATPase family protein associated with various cellular activities (AAA); PFAM: AAA domain (dynein-related subfamily); CbbQ/NirQ/NorQ C-terminal.	0.637
AFL72633.1	AFL72773.1	Thivi_0575	Thivi_0720	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72633.1	AFL72775.1	Thivi_0575	Thivi_0722	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72633.1	AFL74573.1	Thivi_0575	Thivi_2644	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72633.1	AFL74585.1	Thivi_0575	Thivi_2665	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72633.1	AFL74799.1	Thivi_0575	Thivi_2893	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72633.1	AFL74836.1	Thivi_0575	Thivi_2941	PFAM: Siphovirus Gp157.	Hypothetical protein.	0.619
AFL72634.1	AFL72632.1	Thivi_0576	Thivi_0574	ATPase family protein associated with various cellular activities (AAA); PFAM: AAA domain (dynein-related subfamily); CbbQ/NirQ/NorQ C-terminal.	Hypothetical protein.	0.429
AFL72634.1	AFL72633.1	Thivi_0576	Thivi_0575	ATPase family protein associated with various cellular activities (AAA); PFAM: AAA domain (dynein-related subfamily); CbbQ/NirQ/NorQ C-terminal.	PFAM: Siphovirus Gp157.	0.637
AFL72773.1	AFL72633.1	Thivi_0720	Thivi_0575	Hypothetical protein.	PFAM: Siphovirus Gp157.	0.619
AFL72775.1	AFL72633.1	Thivi_0722	Thivi_0575	Hypothetical protein.	PFAM: Siphovirus Gp157.	0.619
AFL74573.1	AFL72633.1	Thivi_2644	Thivi_0575	Hypothetical protein.	PFAM: Siphovirus Gp157.	0.619
AFL74585.1	AFL72633.1	Thivi_2665	Thivi_0575	Hypothetical protein.	PFAM: Siphovirus Gp157.	0.619

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.858

expected number of edges:

13

PPI enrichment p-value:

1.34e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043039

tRNA aminoacylation

8 of 39

2.42

6.8

4.39e-15

GO:0006418

tRNA aminoacylation for protein translation

7 of 36

2.4

5.9

5.29e-13

GO:0006520

Cellular amino acid metabolic process

9 of 249

1.67

3.46

8.77e-12

GO:0006422

aspartyl-tRNA aminoacylation

3 of 3

3.11

3.26

1.18e-06

GO:0006412

Translation

9 of 292

1.6

3.14

2.85e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

7 of 37

2.39

5.8

8.17e-13

GO:0140101

Catalytic activity, acting on a tRNA

8 of 88

2.07

5.04

8.17e-13

GO:0016874

Ligase activity

8 of 171

1.78

3.72

3.38e-11

GO:0004815

aspartate-tRNA ligase activity

3 of 3

3.11

3.2

1.50e-06

GO:0004816

asparagine-tRNA ligase activity

2 of 2

3.11

1.98

0.00026

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

2 of 4

2.81

1.21

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7793

tRNA aminoacylation

8 of 40

2.41

6.83

3.05e-15

CL:7857

tRNA synthetases class II (D, K and N) , and glutamyl-tRNA(Gln) amidotransferase complex

4 of 5

3.01

4.31

1.21e-08

CL:7800

tRNA Aminoacylation

4 of 17

2.48

3.35

3.82e-07

CL:7804

Selenoamino acid metabolism

3 of 11

2.54

2.44

2.74e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

8 of 46

2.35

6.94

6.05e-16

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-379724

tRNA Aminoacylation

6 of 33

2.37

4.85

1.26e-10

MAP-2408522

Selenoamino acid metabolism

4 of 10

2.71

3.77

8.75e-08

MAP-379716

Cytosolic tRNA aminoacylation

4 of 16

2.51

3.48

2.22e-07

MAP-72766

Translation

7 of 250

1.56

2.4

8.75e-08

MAP-379726

Mitochondrial tRNA aminoacylation

3 of 15

2.41

2.26

5.29e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

2 of 4

2.81

1.16

0.0078

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00152

tRNA synthetases class II (D, K and N)

4 of 4

3.11

4.3

1.36e-08

PF01336

OB-fold nucleic acid binding domain

4 of 7

2.87

4.05

3.21e-08

PF03950

tRNA synthetases class I (E and Q), anti-codon binding domain

2 of 2

3.11

1.64

0.0011

PF00749

tRNA synthetases class I (E and Q), catalytic domain

2 of 3

2.93

1.59

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002312

Aspartyl/Asparaginyl-tRNA synthetase, class IIb

4 of 4

3.11

4.07

3.79e-08

IPR004364

Aminoacyl-tRNA synthetase, class II (D/K/N)

4 of 5

3.01

4.05

3.79e-08

IPR004365

OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

4 of 7

2.87

3.91

5.95e-08

IPR006195

Aminoacyl-tRNA synthetase, class II

4 of 13

2.6

3.44

3.21e-07

IPR045864

Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

4 of 19

2.43

3.13

9.54e-07

(more ...)

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