node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGA89350.1 | AGA92110.1 | Thimo_0495 | Thimo_3445 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Phosphorylase superfamily. | 0.522 |
AGA89350.1 | ahcY | Thimo_0495 | Thimo_2179 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.961 |
AGA89350.1 | guaA | Thimo_0495 | Thimo_3599 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.772 |
AGA89350.1 | metG | Thimo_0495 | Thimo_0959 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Protein containing C-terminal region/beta chain of methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.935 |
AGA90918.1 | AGA92110.1 | Thimo_2170 | Thimo_3445 | Cysteine desulfurase family protein; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Aminotransferase class-V; TIGRFAM: cysteine desulfurase NifS; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | PFAM: Phosphorylase superfamily. | 0.600 |
AGA92108.1 | AGA92109.1 | Thimo_3443 | Thimo_3444 | MiaB-like tRNA modifying enzyme; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; radical SAM methylthiotransferase, MiaB/RimO family. | Molecular chaperone (small heat shock protein). | 0.659 |
AGA92108.1 | AGA92110.1 | Thimo_3443 | Thimo_3445 | MiaB-like tRNA modifying enzyme; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; radical SAM methylthiotransferase, MiaB/RimO family. | PFAM: Phosphorylase superfamily. | 0.450 |
AGA92109.1 | AGA92108.1 | Thimo_3444 | Thimo_3443 | Molecular chaperone (small heat shock protein). | MiaB-like tRNA modifying enzyme; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; radical SAM methylthiotransferase, MiaB/RimO family. | 0.659 |
AGA92109.1 | AGA92110.1 | Thimo_3444 | Thimo_3445 | Molecular chaperone (small heat shock protein). | PFAM: Phosphorylase superfamily. | 0.530 |
AGA92110.1 | AGA89350.1 | Thimo_3445 | Thimo_0495 | PFAM: Phosphorylase superfamily. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.522 |
AGA92110.1 | AGA90918.1 | Thimo_3445 | Thimo_2170 | PFAM: Phosphorylase superfamily. | Cysteine desulfurase family protein; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Aminotransferase class-V; TIGRFAM: cysteine desulfurase NifS; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.600 |
AGA92110.1 | AGA92108.1 | Thimo_3445 | Thimo_3443 | PFAM: Phosphorylase superfamily. | MiaB-like tRNA modifying enzyme; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; radical SAM methylthiotransferase, MiaB/RimO family. | 0.450 |
AGA92110.1 | AGA92109.1 | Thimo_3445 | Thimo_3444 | PFAM: Phosphorylase superfamily. | Molecular chaperone (small heat shock protein). | 0.530 |
AGA92110.1 | ahcY | Thimo_3445 | Thimo_2179 | PFAM: Phosphorylase superfamily. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.920 |
AGA92110.1 | guaA | Thimo_3445 | Thimo_3599 | PFAM: Phosphorylase superfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.488 |
AGA92110.1 | metG | Thimo_3445 | Thimo_0959 | PFAM: Phosphorylase superfamily. | Protein containing C-terminal region/beta chain of methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.472 |
AGA92110.1 | mtaD | Thimo_3445 | Thimo_1291 | PFAM: Phosphorylase superfamily. | Cytosine deaminase-like metal-dependent hydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. | 0.910 |
AGA92110.1 | nadE | Thimo_3445 | Thimo_2189 | PFAM: Phosphorylase superfamily. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.502 |
AGA92110.1 | speE | Thimo_3445 | Thimo_0096 | PFAM: Phosphorylase superfamily. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.900 |
ahcY | AGA89350.1 | Thimo_2179 | Thimo_0495 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.961 |