STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGV32671.1KEGG: cob:COB47_2250 ATPase AAA-2 domain protein; PFAM: ATPase associated with various cellular activities, AAA-2; SMART: ATPase, AAA+ type, core. (611 aa)    
Predicted Functional Partners:
clpP
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.977
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.974
EGV30305.1
KEGG: alv:Alvin_1475 DnaK-like protein; Belongs to the heat shock protein 70 family.
  
 
 0.970
EGV31177.1
KEGG: psl:Psta_1832 type VI secretion protein, EvpB/VC_A0108 family; TIGRFAM: Protein of unknown function DUF877; PFAM: Protein of unknown function DUF877.
 
 0.960
clpS
ATP-dependent Clp protease adapter protein clpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
  
 
 0.954
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.846
EGV28448.1
TIGRFAM: PAS; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; Extracellular solute-binding protein, family 3; PAS fold-3; PAS fold; KEGG: alv:Alvin_2334 multi-sensor hybrid histidine kinase; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS.
 
 
 
 0.844
EGV27912.1
PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: PAS; PFAM: ATP-binding region, ATPase-like; NMT1/THI5 like; Extracellular solute-binding protein, family 3; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; KEGG: mgm:Mmc1_2394 multi-sensor hybrid histidine kinase; SMART: ATP-binding region, ATPase-like; Extracellular solute-binding protein, family 3; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region.
 
 
 
 0.837
EGV30948.1
Multi-sensor hybrid histidine kinase; TIGRFAM: PAS; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; PAS fold; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, phosphotransfer (Hpt) region; KEGG: dal:Dalk_0544 multi-sensor hybrid histidine kinase; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; PAS; Signal transduction response regulator, receiver [...]
 
 
 
 0.823
EGV28447.1
Hypothetical protein; KEGG: alv:Alvin_2334 multi-sensor hybrid histidine kinase.
   
 
 0.794
Your Current Organism:
Thiorhodococcus drewsii
NCBI taxonomy Id: 765913
Other names: T. drewsii AZ1, Thiorhodococcus drewsii AZ1, Thiorhodococcus drewsii DSM 15006, Thiorhodococcus drewsii str. AZ1, Thiorhodococcus drewsii strain AZ1
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