STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGZ48491.1KEGG: pmy:Pmen_2578 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; TIGRFAM: Aconitase B, bacterial; PFAM: Aconitase B, N-terminal, bacterial; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Belongs to the aconitase/IPM isomerase family. (868 aa)    
Predicted Functional Partners:
EGZ50888.1
TIGRFAM: Citrate synthase, type II; KEGG: tgr:Tgr7_1301 citrate (Si)-synthase; PFAM: Citrate synthase-like; Belongs to the citrate synthase family.
  
 
 0.982
EGZ43646.1
TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic; KEGG: tgr:Tgr7_1840 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase.
  
 
 0.974
sucC
Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.958
EGZ44815.1
Pyruvate dehydrogenase (NADP(+))., Pyruvate synthase; KEGG: hha:Hhal_0066 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding.
   
 
 0.939
EGZ48489.1
TIGRFAM: Isocitrate lyase; KEGG: tgr:Tgr7_2552 isocitrate lyase; PFAM: Isocitrate lyase/phosphorylmutase.
    
 0.933
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
  
 0.932
EGZ44242.1
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
 
  
 0.932
EGZ48685.1
TIGRFAM: 2-methylcitrate dehydratase PrpD; KEGG: tgr:Tgr7_1507 2-methylcitrate dehydratase; PFAM: MmgE/PrpD.
 
   
 0.924
EGZ49664.1
TIGRFAM: 2-methylcitrate synthase/citrate synthase type I; KEGG: tgr:Tgr7_1508 methylcitrate synthase; PFAM: Citrate synthase-like; Belongs to the citrate synthase family.
  
 
 0.917
EGZ47568.1
2-oxoglutarate dehydrogenase, E1 subunit; SMART: Transketolase-like, pyrimidine-binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component; KEGG: tgr:Tgr7_0079 alpha-ketoglutarate decarboxylase; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component.
   
  
 0.916
Your Current Organism:
Thiorhodospira sibirica
NCBI taxonomy Id: 765914
Other names: T. sibirica ATCC 700588, Thiorhodospira sibirica A12, Thiorhodospira sibirica ATCC 700588, Thiorhodospira sibirica str. ATCC 700588, Thiorhodospira sibirica strain ATCC 700588
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