STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W4ZA14_STRPUUncharacterized protein. (163 aa)    
Predicted Functional Partners:
W4YLG1_STRPU
Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.
   
 
 0.884
W4X9V2_STRPU
Importin N-terminal domain-containing protein.
    
 
 0.644
W4XRX8_STRPU
ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.
    
 
 0.597
H2A.F/Z
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...]
    
 
 0.461
H2A.F/Z-2
Histone H2A; Belongs to the histone H2A family.
    
 
 0.461
W4ZEA8_STRPU
Histone H2A; Belongs to the histone H2A family.
    
 
 0.461
W4Z2Q3_STRPU
Importin N-terminal domain-containing protein.
      
 0.432
W4ZHR1_STRPU
Importin N-terminal domain-containing protein.
      
 0.432
H3JPQ4_STRPU
Profilin; Belongs to the profilin family.
   
  
 0.423
Coel1
Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
   
  
 0.423
Your Current Organism:
Strongylocentrotus purpuratus
NCBI taxonomy Id: 7668
Other names: S. purpuratus, purple sea urchin, purple urchin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.