AFN46539.1 protein (Pseudopropionibacterium propionicum)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

AFN46539.1

Hypothetical protein. (54 aa)

Predicted Functional Partners:

AFN44918.1

0.498

AFN45532.1

0.455

AFN46614.1

0.455

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN44918.1	AFN45532.1	HMPREF9154_0068	HMPREF9154_0066	Hypothetical protein.	Nitroreductase family protein.	0.697
AFN44918.1	AFN46539.1	HMPREF9154_0068	HMPREF9154_0069	Hypothetical protein.	Hypothetical protein.	0.498
AFN44918.1	AFN46614.1	HMPREF9154_0068	HMPREF9154_0067	Hypothetical protein.	YcaO-like protein.	0.697
AFN45532.1	AFN44918.1	HMPREF9154_0066	HMPREF9154_0068	Nitroreductase family protein.	Hypothetical protein.	0.697
AFN45532.1	AFN46539.1	HMPREF9154_0066	HMPREF9154_0069	Nitroreductase family protein.	Hypothetical protein.	0.455
AFN45532.1	AFN46614.1	HMPREF9154_0066	HMPREF9154_0067	Nitroreductase family protein.	YcaO-like protein.	0.975
AFN46539.1	AFN44918.1	HMPREF9154_0069	HMPREF9154_0068	Hypothetical protein.	Hypothetical protein.	0.498
AFN46539.1	AFN45532.1	HMPREF9154_0069	HMPREF9154_0066	Hypothetical protein.	Nitroreductase family protein.	0.455
AFN46539.1	AFN46614.1	HMPREF9154_0069	HMPREF9154_0067	Hypothetical protein.	YcaO-like protein.	0.455
AFN46614.1	AFN44918.1	HMPREF9154_0067	HMPREF9154_0068	YcaO-like protein.	Hypothetical protein.	0.697
AFN46614.1	AFN45532.1	HMPREF9154_0067	HMPREF9154_0066	YcaO-like protein.	Nitroreductase family protein.	0.975
AFN46614.1	AFN46539.1	HMPREF9154_0067	HMPREF9154_0069	YcaO-like protein.	Hypothetical protein.	0.455

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.589

expected number of edges:

10

PPI enrichment p-value:

7.05e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

4 of 8

3.02

3.79

1.16e-07

GO:0098974

Postsynaptic actin cytoskeleton organization

4 of 15

2.74

3.41

4.54e-07

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

4 of 15

2.74

3.41

4.54e-07

GO:1901385

Regulation of voltage-gated calcium channel activity

4 of 39

2.33

2.78

4.11e-06

GO:0002027

Regulation of heart rate

4 of 40

2.32

2.77

4.11e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

4 of 8

3.02

4.04

3.84e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016010

Dystrophin-associated glycoprotein complex

4 of 14

2.77

3.74

1.11e-07

GO:0002102

Podosome

4 of 18

2.66

3.66

1.33e-07

GO:0033017

Sarcoplasmic reticulum membrane

4 of 31

2.43

3.28

4.74e-07

GO:0030175

Filopodium

4 of 72

2.06

2.57

5.11e-06

GO:0030018

Z disc

4 of 102

1.91

2.24

1.61e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36908

Mixed, incl. Dystrophin-associated glycoprotein complex, and EF hand

7 of 31

2.67

6.88

3.20e-14

CL:36910

EF hand, and Syntrophin

4 of 12

2.84

3.88

6.57e-08

CL:36947

Mixed, incl. Torsin 1/2, and Torsin-1A-interacting protein 1/2

3 of 10

2.79

2.56

1.97e-05

CL:36950

Nitric-oxide synthase binding, and Torsin 1/2

2 of 5

2.92

1.39

0.0031

CL:36912

Mixed, incl. EF hand, and Syntrophin, split Pleckstrin homology (PH) domain

2 of 7

2.77

1.28

0.0047

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 407

1.31

1.26

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016010

Dystrophin-associated glycoprotein complex

5 of 24

2.64

4.6

1.60e-09

GOCC:0045202

Synapse

4 of 531

1.19

0.68

0.0232

GOCC:0016020

Membrane

9 of 5135

0.56

0.38

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015482

Syntrophin

4 of 4

3.32

4.32

1.44e-08

IPR041428

Syntrophin, split Pleckstrin homology (PH) domain

3 of 3

3.32

2.98

4.04e-06

IPR011993

PH-like domain superfamily

7 of 529

1.44

1.83

4.04e-06

IPR006020

PTB/PI domain

3 of 57

2.04

1.28

0.0035

IPR001478

PDZ domain

4 of 201

1.62

1.15

0.0035

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

3 of 39

2.2

1.64

0.00073

SM00233

Pleckstrin homology domain.

4 of 325

1.41

0.99

0.0050

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