AFN46807.1 protein (Pseudopropionibacterium propionicum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Coexpression

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[Homology]

Score

AFN46807.1

Glycosyltransferase, group 2 family protein. (427 aa)

Predicted Functional Partners:

AFN47598.1

0.980

AFN45964.1

0.871

AFN45113.1

0.860

AFN47463.1

0.550

AFN46757.1

0.515

AFN46369.1

0.513

AFN47201.1

0.439

AFN45907.1

0.439

AFN45915.1

0.439

AFN47680.1

0.439

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45113.1	AFN45964.1	HMPREF9154_0168	HMPREF9154_0167	N-acetylglucosaminylphosphatidylinositol deacetylase.	ATP-grasp domain protein.	0.871
AFN45113.1	AFN46807.1	HMPREF9154_0168	HMPREF9154_0166	N-acetylglucosaminylphosphatidylinositol deacetylase.	Glycosyltransferase, group 2 family protein.	0.860
AFN45113.1	AFN47598.1	HMPREF9154_0168	HMPREF9154_0165	N-acetylglucosaminylphosphatidylinositol deacetylase.	Hypothetical protein.	0.793
AFN45907.1	AFN46807.1	HMPREF9154_0375	HMPREF9154_0166	Hypothetical protein.	Glycosyltransferase, group 2 family protein.	0.439
AFN45907.1	AFN47201.1	HMPREF9154_0375	HMPREF9154_0373	Hypothetical protein.	Hypothetical protein.	0.543
AFN45907.1	AFN47463.1	HMPREF9154_0375	HMPREF9154_1027	Hypothetical protein.	KR domain protein.	0.619
AFN45915.1	AFN46807.1	HMPREF9154_1958	HMPREF9154_0166	Hypothetical protein.	Glycosyltransferase, group 2 family protein.	0.439
AFN45915.1	AFN47463.1	HMPREF9154_1958	HMPREF9154_1027	Hypothetical protein.	KR domain protein.	0.462
AFN45964.1	AFN45113.1	HMPREF9154_0167	HMPREF9154_0168	ATP-grasp domain protein.	N-acetylglucosaminylphosphatidylinositol deacetylase.	0.871
AFN45964.1	AFN46807.1	HMPREF9154_0167	HMPREF9154_0166	ATP-grasp domain protein.	Glycosyltransferase, group 2 family protein.	0.871
AFN45964.1	AFN47463.1	HMPREF9154_0167	HMPREF9154_1027	ATP-grasp domain protein.	KR domain protein.	0.524
AFN45964.1	AFN47598.1	HMPREF9154_0167	HMPREF9154_0165	ATP-grasp domain protein.	Hypothetical protein.	0.824
AFN46369.1	AFN46807.1	HMPREF9154_1043	HMPREF9154_0166	Polysaccharide deacetylase.	Glycosyltransferase, group 2 family protein.	0.513
AFN46369.1	AFN47463.1	HMPREF9154_1043	HMPREF9154_1027	Polysaccharide deacetylase.	KR domain protein.	0.552
AFN46757.1	AFN46807.1	HMPREF9154_0677	HMPREF9154_0166	Polysaccharide deacetylase.	Glycosyltransferase, group 2 family protein.	0.515
AFN46757.1	AFN47463.1	HMPREF9154_0677	HMPREF9154_1027	Polysaccharide deacetylase.	KR domain protein.	0.552
AFN46807.1	AFN45113.1	HMPREF9154_0166	HMPREF9154_0168	Glycosyltransferase, group 2 family protein.	N-acetylglucosaminylphosphatidylinositol deacetylase.	0.860
AFN46807.1	AFN45907.1	HMPREF9154_0166	HMPREF9154_0375	Glycosyltransferase, group 2 family protein.	Hypothetical protein.	0.439
AFN46807.1	AFN45915.1	HMPREF9154_0166	HMPREF9154_1958	Glycosyltransferase, group 2 family protein.	Hypothetical protein.	0.439
AFN46807.1	AFN45964.1	HMPREF9154_0166	HMPREF9154_0167	Glycosyltransferase, group 2 family protein.	ATP-grasp domain protein.	0.871

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045664

Regulation of neuron differentiation

6 of 80

2.19

3.85

8.75e-09

GO:0045666

Positive regulation of neuron differentiation

5 of 40

2.41

3.76

4.36e-08

GO:0001711

Endodermal cell fate commitment

2 of 3

3.14

1.83

0.00049

GO:0045597

Positive regulation of cell differentiation

6 of 478

1.42

1.69

1.34e-05

GO:0045944

Positive regulation of transcription by RNA polymerase II

8 of 880

1.28

1.66

7.57e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

7 of 32

2.66

6.95

2.09e-14

GO:0008134

Transcription factor binding

7 of 358

1.61

2.49

1.04e-07

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 252

1.69

2.43

7.66e-07

GO:0046982

Protein heterodimerization activity

6 of 258

1.68

2.41

7.66e-07

GO:0046983

Protein dimerization activity

7 of 842

1.24

1.42

1.23e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 371

1.59

2.44

1.25e-07

GO:0016593

Cdc73/Paf1 complex

2 of 9

2.66

1.27

0.0048

GO:0005721

Pericentric heterochromatin

2 of 18

2.36

1.03

0.0125

GO:0005634

Nucleus

11 of 6688

0.53

0.43

0.00085

GO:0032991

Protein-containing complex

9 of 5100

0.56

0.39

0.0125

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

0.77

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31959

Myogenesis, and DNA-binding protein inhibitor

6 of 24

2.72

5.82

6.88e-12

CL:31867

Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and RUNX1 regulates transcription of genes involved in differentiation of HSCs

7 of 114

2.11

4.48

7.89e-11

CL:31960

MADS MEF2-like, and Myogenic factor

3 of 15

2.62

2.36

4.20e-05

CL:10560

Endodermal cell fate commitment, and Spinal cord oligodendrocyte cell differentiation

2 of 5

2.92

1.45

0.0024

CL:31990

DNA-binding protein inhibitor, and Positive regulation of skeletal muscle fiber development

2 of 6

2.84

1.4

0.0029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

5 of 54

2.28

3.55

7.30e-08

MAP-1266738

Developmental Biology

6 of 811

1.19

1.06

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.72

1.23

0.0058

GOCC:0005721

Pericentric heterochromatin

2 of 7

2.77

1.23

0.0058

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0150

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

5 of 144

1.86

2.07

3.49e-05

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

5 of 145

1.86

2.07

3.49e-05

IPR008251

Chromo shadow domain

2 of 5

2.92

1.1

0.0104

IPR017984

Chromo domain subgroup

2 of 10

2.62

0.89

0.0246

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

5 of 149

1.84

2.38

4.51e-06

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