AFN47514.1 protein (Pseudopropionibacterium propionicum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

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[Homology]

Score

AFN47514.1

Putative lipoprotein. (268 aa)

Predicted Functional Partners:

AFN45943.1

0.657

AFN47249.1

0.645

malL

0.538

AFN47463.1

0.415

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45943.1	AFN47463.1	HMPREF9154_2356	HMPREF9154_1027	Hypothetical protein.	KR domain protein.	0.460
AFN45943.1	AFN47514.1	HMPREF9154_2356	HMPREF9154_0316	Hypothetical protein.	Putative lipoprotein.	0.657
AFN47249.1	AFN47514.1	HMPREF9154_0317	HMPREF9154_0316	Hypothetical protein.	Putative lipoprotein.	0.645
AFN47249.1	malL	HMPREF9154_0317	HMPREF9154_0315	Hypothetical protein.	Oligo-1,6-glucosidase.	0.457
AFN47463.1	AFN45943.1	HMPREF9154_1027	HMPREF9154_2356	KR domain protein.	Hypothetical protein.	0.460
AFN47463.1	AFN47514.1	HMPREF9154_1027	HMPREF9154_0316	KR domain protein.	Putative lipoprotein.	0.415
AFN47514.1	AFN45943.1	HMPREF9154_0316	HMPREF9154_2356	Putative lipoprotein.	Hypothetical protein.	0.657
AFN47514.1	AFN47249.1	HMPREF9154_0316	HMPREF9154_0317	Putative lipoprotein.	Hypothetical protein.	0.645
AFN47514.1	AFN47463.1	HMPREF9154_0316	HMPREF9154_1027	Putative lipoprotein.	KR domain protein.	0.415
AFN47514.1	malL	HMPREF9154_0316	HMPREF9154_0315	Putative lipoprotein.	Oligo-1,6-glucosidase.	0.538
malL	AFN47249.1	HMPREF9154_0315	HMPREF9154_0317	Oligo-1,6-glucosidase.	Hypothetical protein.	0.457
malL	AFN47514.1	HMPREF9154_0315	HMPREF9154_0316	Oligo-1,6-glucosidase.	Putative lipoprotein.	0.538

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.908

expected number of edges:

10

PPI enrichment p-value:

9.94e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901621

Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

4 of 5

3.22

4.14

2.96e-08

GO:0010737

Protein kinase A signaling

4 of 12

2.84

3.7

1.42e-07

GO:0070613

Regulation of protein processing

4 of 40

2.32

2.75

4.52e-06

GO:0001843

Neural tube closure

4 of 43

2.29

2.73

4.61e-06

GO:0005513

Detection of calcium ion

2 of 4

3.02

1.64

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004690

Cyclic nucleotide-dependent protein kinase activity

5 of 15

2.84

5.04

3.67e-10

GO:0004691

cAMP-dependent protein kinase activity

4 of 6

3.14

4.43

8.14e-09

GO:0004679

AMP-activated protein kinase activity

4 of 7

3.07

4.41

8.53e-09

GO:0022839

Ion gated channel activity

4 of 36

2.36

3.05

1.17e-06

GO:0005267

Potassium channel activity

6 of 173

1.86

3.03

6.34e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097546

Ciliary base

4 of 25

2.52

3.19

8.61e-07

GO:0005813

Centrosome

4 of 419

1.3

0.83

0.0108

GO:0005886

Plasma membrane

11 of 5511

0.62

0.54

0.00010

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38343157

(2024) Identification of Philaster apodigitiformis in aquaculture and functional characterization of its beta-PKA gene and expression analysis of infected Poecilia reticulata.

4 of 4

3.32

4.83

1.67e-09

PMID:29491911

(2016) Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms.

4 of 5

3.22

4.82

1.67e-09

PMID:29104539

(2017) Annonaceae: Breaking the Wall of Inflammation.

4 of 9

2.97

4.47

5.66e-09

PMID:36430661

(2022) Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.

4 of 22

2.58

3.71

8.85e-08

PMID:27571066

(2016) Sexually Dimorphic Gene Expression Associated with Growth and Reproduction of Tongue Sole (Cynoglossus semilaevis) Revealed by Brain Transcriptome Analysis.

4 of 26

2.5

3.59

1.30e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26060

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and PKA activation in glucagon signalling

11 of 41

2.75

12.53

1.35e-26

CL:26127

Detection of calcium ion, and Calcium-activated BK potassium channel alpha subunit

5 of 6

3.24

6.17

5.11e-12

CL:26061

Cyclic nucleotide-dependent protein kinase activity, and PKA activation in glucagon signalling

5 of 33

2.5

4.29

4.42e-09

CL:26065

PKA activation in glucagon signalling, and Hormone-sensitive lipase, N-terminal

4 of 11

2.88

4.05

3.28e-08

CL:26068

PKA activation in glucagon signalling

3 of 6

3.02

2.94

4.34e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04270

Vascular smooth muscle contraction

7 of 128

2.06

4.64

1.15e-11

pret04540

Gap junction

5 of 103

2.0

3.22

8.02e-08

pret04340

Hedgehog signaling pathway

4 of 53

2.2

3.07

6.25e-07

pret04914

Progesterone-mediated oocyte maturation

4 of 88

1.98

2.57

3.29e-06

pret04912

GnRH signaling pathway

4 of 94

1.95

2.54

3.40e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-392517

Rap1 signalling

5 of 30

2.54

4.31

4.76e-09

MAP-164378

PKA activation in glucagon signalling

4 of 12

2.84

3.97

4.37e-08

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

4 of 13

2.81

3.96

4.37e-08

MAP-163359

Glucagon signaling in metabolic regulation

4 of 13

2.81

3.96

4.37e-08

MAP-8963896

HDL assembly

4 of 20

2.62

3.7

1.02e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0048471

Perinuclear region of cytoplasm

4 of 66

2.1

2.2

4.00e-05

GOCC:0005929

Cilium

4 of 396

1.32

0.74

0.0211

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

5 of 233

1.65

1.97

1.72e-05

KW-0067

ATP-binding

5 of 940

1.04

0.76

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03493

Calcium-activated BK potassium channel alpha subunit

4 of 4

3.32

4.59

4.60e-09

PF07885

Ion channel

4 of 91

1.96

1.95

0.00010

PF03185

Calcium-activated potassium channel, beta subunit

2 of 4

3.02

1.45

0.0024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044109

cAMP-dependent protein kinase catalytic subunit

4 of 4

3.32

4.32

1.44e-08

IPR003929

Calcium-activated potassium channel BK, alpha subunit

4 of 4

3.32

4.32

1.44e-08

IPR000961

AGC-kinase, C-terminal

5 of 66

2.2

3.23

2.69e-07

IPR003930

Potassium channel, calcium-activated, BK, beta subunit

2 of 4

3.02

1.35

0.0037

IPR008271

Serine/threonine-protein kinase, active site

5 of 369

1.45

1.26

0.00086

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

5 of 63

2.22

3.49

7.09e-08

SM00220

Serine/Threonine protein kinases, catalytic domain

5 of 273

1.58

1.77

4.33e-05

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