clpC protein (Pseudopropionibacterium propionicum)

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clpC

Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. (831 aa)

Predicted Functional Partners:

dnaK

0.975

clpP

0.953

AFN47404.1

0.952

clpS

0.878

clpP-2

0.862

grpE

0.851

dnaJ-2

0.719

dnaJ

0.706

groS

0.688

ptsP_2

0.576

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN47404.1	clpC	HMPREF9154_1298	HMPREF9154_0429	Arsenite-activated ATPase ArsA.	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	0.952
AFN47404.1	dnaJ	HMPREF9154_1298	HMPREF9154_2563	Arsenite-activated ATPase ArsA.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.703
AFN47404.1	dnaJ-2	HMPREF9154_1298	HMPREF9154_1730	Arsenite-activated ATPase ArsA.	Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...]	0.703
AFN47404.1	dnaK	HMPREF9154_1298	HMPREF9154_2565	Arsenite-activated ATPase ArsA.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.819
AFN47404.1	grpE	HMPREF9154_1298	HMPREF9154_2564	Arsenite-activated ATPase ArsA.	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	0.672
clpC	AFN47404.1	HMPREF9154_0429	HMPREF9154_1298	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Arsenite-activated ATPase ArsA.	0.952
clpC	clpP	HMPREF9154_0429	HMPREF9154_1836	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.953
clpC	clpP-2	HMPREF9154_0429	HMPREF9154_1837	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.862
clpC	clpS	HMPREF9154_0429	HMPREF9154_0971	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family.	0.878
clpC	dnaJ	HMPREF9154_0429	HMPREF9154_2563	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.706
clpC	dnaJ-2	HMPREF9154_0429	HMPREF9154_1730	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...]	0.719
clpC	dnaK	HMPREF9154_0429	HMPREF9154_2565	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.975
clpC	groS	HMPREF9154_0429	HMPREF9154_2153	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.688
clpC	grpE	HMPREF9154_0429	HMPREF9154_2564	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	0.851
clpC	ptsP_2	HMPREF9154_0429	HMPREF9154_0869	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	Phosphoenolpyruvate-protein phosphotransferase.	0.576
clpP	clpC	HMPREF9154_1836	HMPREF9154_0429	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	0.953
clpP	clpP-2	HMPREF9154_1836	HMPREF9154_1837	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.997
clpP	clpS	HMPREF9154_1836	HMPREF9154_0971	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family.	0.633
clpP	dnaK	HMPREF9154_1836	HMPREF9154_2565	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.750
clpP	groS	HMPREF9154_1836	HMPREF9154_2153	Putative ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.735