AFN47630.1 protein (Pseudopropionibacterium propionicum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Score

AFN47630.1

Proline dehydrogenase. (302 aa)

Predicted Functional Partners:

proC

0.979

AFN45610.1

0.920

AFN45127.1

0.824

putP

0.758

cydA

0.540

AFN45936.1

0.536

AFN47361.1

0.510

rocF

0.510

nifJ

0.467

mmsA

0.466

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45127.1	AFN45936.1	HMPREF9154_0436	HMPREF9154_0435	AP endonuclease, family 2.	Hypothetical protein.	0.701
AFN45127.1	AFN47361.1	HMPREF9154_0436	HMPREF9154_0438	AP endonuclease, family 2.	Hypothetical protein.	0.510
AFN45127.1	AFN47630.1	HMPREF9154_0436	HMPREF9154_0437	AP endonuclease, family 2.	Proline dehydrogenase.	0.824
AFN45127.1	proC	HMPREF9154_0436	HMPREF9154_0441	AP endonuclease, family 2.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.495
AFN45610.1	AFN47630.1	HMPREF9154_2632	HMPREF9154_0437	Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Proline dehydrogenase.	0.920
AFN45610.1	mmsA	HMPREF9154_2632	HMPREF9154_0205	Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Methylmalonate-semialdehyde dehydrogenase (acylating).	0.432
AFN45610.1	nifJ	HMPREF9154_2632	HMPREF9154_0751	Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Pyruvate synthase.	0.835
AFN45610.1	proC	HMPREF9154_2632	HMPREF9154_0441	Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.972
AFN45610.1	putP	HMPREF9154_2632	HMPREF9154_2034	Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.988
AFN45610.1	rocF	HMPREF9154_2632	HMPREF9154_2092	Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Arginase; Belongs to the arginase family.	0.555
AFN45936.1	AFN45127.1	HMPREF9154_0435	HMPREF9154_0436	Hypothetical protein.	AP endonuclease, family 2.	0.701
AFN45936.1	AFN47630.1	HMPREF9154_0435	HMPREF9154_0437	Hypothetical protein.	Proline dehydrogenase.	0.536
AFN47361.1	AFN45127.1	HMPREF9154_0438	HMPREF9154_0436	Hypothetical protein.	AP endonuclease, family 2.	0.510
AFN47361.1	AFN47630.1	HMPREF9154_0438	HMPREF9154_0437	Hypothetical protein.	Proline dehydrogenase.	0.510
AFN47630.1	AFN45127.1	HMPREF9154_0437	HMPREF9154_0436	Proline dehydrogenase.	AP endonuclease, family 2.	0.824
AFN47630.1	AFN45610.1	HMPREF9154_0437	HMPREF9154_2632	Proline dehydrogenase.	Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.920
AFN47630.1	AFN45936.1	HMPREF9154_0437	HMPREF9154_0435	Proline dehydrogenase.	Hypothetical protein.	0.536
AFN47630.1	AFN47361.1	HMPREF9154_0437	HMPREF9154_0438	Proline dehydrogenase.	Hypothetical protein.	0.510
AFN47630.1	cydA	HMPREF9154_0437	HMPREF9154_0284	Proline dehydrogenase.	Cytochrome d ubiquinol oxidase, subunit I.	0.540
AFN47630.1	mmsA	HMPREF9154_0437	HMPREF9154_0205	Proline dehydrogenase.	Methylmalonate-semialdehyde dehydrogenase (acylating).	0.466

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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