AFN45236.1 protein (Pseudopropionibacterium propionicum)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AFN45236.1

McrBC 5-methylcytosine restriction system component. (347 aa)

Predicted Functional Partners:

AFN45701.1

0.998

AFN45933.1

0.721

AFN46563.1

0.697

AFN47235.1

0.651

AFN47002.1

0.646

AFN46496.1

0.598

AFN46882.1

0.580

AFN47003.1

0.526

AFN46550.1

0.501

AFN47192.1

0.472

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45236.1	AFN45701.1	HMPREF9154_0455	HMPREF9154_0454	McrBC 5-methylcytosine restriction system component.	Hypothetical protein.	0.998
AFN45236.1	AFN45933.1	HMPREF9154_0455	HMPREF9154_2464	McrBC 5-methylcytosine restriction system component.	Putative membrane protein.	0.721
AFN45236.1	AFN46496.1	HMPREF9154_0455	HMPREF9154_1980	McrBC 5-methylcytosine restriction system component.	Hypothetical protein.	0.598
AFN45236.1	AFN46550.1	HMPREF9154_0455	HMPREF9154_0362	McrBC 5-methylcytosine restriction system component.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.501
AFN45236.1	AFN46563.1	HMPREF9154_0455	HMPREF9154_2465	McrBC 5-methylcytosine restriction system component.	Hypothetical protein.	0.697
AFN45236.1	AFN46882.1	HMPREF9154_0455	HMPREF9154_2462	McrBC 5-methylcytosine restriction system component.	Histidine kinase.	0.580
AFN45236.1	AFN47002.1	HMPREF9154_0455	HMPREF9154_3143	McrBC 5-methylcytosine restriction system component.	Hypothetical protein.	0.646
AFN45236.1	AFN47003.1	HMPREF9154_0455	HMPREF9154_3010	McrBC 5-methylcytosine restriction system component.	Glycosyl hydrolase family 16.	0.526
AFN45236.1	AFN47192.1	HMPREF9154_0455	HMPREF9154_2635	McrBC 5-methylcytosine restriction system component.	Cysteine-rich secretory family protein.	0.472
AFN45236.1	AFN47235.1	HMPREF9154_0455	HMPREF9154_1982	McrBC 5-methylcytosine restriction system component.	CRISPR-associated RAMP protein.	0.651
AFN45701.1	AFN45236.1	HMPREF9154_0454	HMPREF9154_0455	Hypothetical protein.	McrBC 5-methylcytosine restriction system component.	0.998
AFN45701.1	AFN45933.1	HMPREF9154_0454	HMPREF9154_2464	Hypothetical protein.	Putative membrane protein.	0.497
AFN45701.1	AFN46563.1	HMPREF9154_0454	HMPREF9154_2465	Hypothetical protein.	Hypothetical protein.	0.438
AFN45701.1	AFN47235.1	HMPREF9154_0454	HMPREF9154_1982	Hypothetical protein.	CRISPR-associated RAMP protein.	0.413
AFN45933.1	AFN45236.1	HMPREF9154_2464	HMPREF9154_0455	Putative membrane protein.	McrBC 5-methylcytosine restriction system component.	0.721
AFN45933.1	AFN45701.1	HMPREF9154_2464	HMPREF9154_0454	Putative membrane protein.	Hypothetical protein.	0.497
AFN45933.1	AFN46496.1	HMPREF9154_2464	HMPREF9154_1980	Putative membrane protein.	Hypothetical protein.	0.722
AFN45933.1	AFN46550.1	HMPREF9154_2464	HMPREF9154_0362	Putative membrane protein.	ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.	0.732
AFN45933.1	AFN46563.1	HMPREF9154_2464	HMPREF9154_2465	Putative membrane protein.	Hypothetical protein.	0.958
AFN45933.1	AFN46882.1	HMPREF9154_2464	HMPREF9154_2462	Putative membrane protein.	Histidine kinase.	0.891

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.865

expected number of edges:

11

PPI enrichment p-value:

0.00479

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006325

Chromatin organization

7 of 181

1.11

0.97

0.00072

GO:0016571

Histone methylation

3 of 17

1.77

0.76

0.0339

GO:0031497

Chromatin assembly

4 of 75

1.25

0.6

0.0450

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035097

Histone methyltransferase complex

3 of 13

1.88

1.04

0.0094

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1126

Histone methylation, and Structural constituent of chromatin

9 of 28

2.03

5.49

7.82e-15

CL:1122

Mixed, incl. Histone methylation, and Structural constituent of chromatin

10 of 46

1.86

4.89

2.47e-15

CL:1128

Histone lysine methylation, and Structural constituent of chromatin

6 of 21

1.98

3.66

3.28e-09

CL:1129

Structural constituent of chromatin, and AWS domain

4 of 15

1.95

2.32

1.22e-05

CL:1172

Regulation of PTEN gene transcription, and JmjN domain

3 of 5

2.3

2.16

7.43e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04130

SNARE interactions in vesicular transport

3 of 24

1.62

1.02

0.0072

map04145

Phagosome

3 of 39

1.41

0.84

0.0138

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

3 of 11

1.95

1.16

0.0057

MAP-4839726

Chromatin organization

4 of 58

1.36

0.88

0.0089

MAP-3247509

Chromatin modifying enzymes

4 of 58

1.36

0.88

0.0089

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 11

1.95

1.14

0.0062

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