| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFN44982.1 | AFN45610.1 | HMPREF9154_1209 | HMPREF9154_2632 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.933 |
| AFN44982.1 | AFN46907.1 | HMPREF9154_1209 | HMPREF9154_2617 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | 0.928 |
| AFN44982.1 | gdhA | HMPREF9154_1209 | HMPREF9154_1115 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | NAD(P)-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.958 |
| AFN44982.1 | glnA | HMPREF9154_1209 | HMPREF9154_1223 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Glutamine synthetase, type I. | 0.920 |
| AFN44982.1 | murI | HMPREF9154_1209 | HMPREF9154_0973 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.822 |
| AFN44982.1 | purQ | HMPREF9154_1209 | HMPREF9154_0513 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.906 |
| AFN45610.1 | AFN44982.1 | HMPREF9154_2632 | HMPREF9154_1209 | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | 0.933 |
| AFN45610.1 | AFN46907.1 | HMPREF9154_2632 | HMPREF9154_2617 | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | 0.933 |
| AFN45610.1 | clpS | HMPREF9154_2632 | HMPREF9154_0971 | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | 0.412 |
| AFN45610.1 | gdhA | HMPREF9154_2632 | HMPREF9154_1115 | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | NAD(P)-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.954 |
| AFN45610.1 | glnA | HMPREF9154_2632 | HMPREF9154_1223 | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Glutamine synthetase, type I. | 0.933 |
| AFN45610.1 | murI | HMPREF9154_2632 | HMPREF9154_0973 | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.873 |
| AFN45610.1 | purQ | HMPREF9154_2632 | HMPREF9154_0513 | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.902 |
| AFN46500.1 | clpS | HMPREF9154_0972 | HMPREF9154_0971 | Hypothetical protein. | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | 0.859 |
| AFN46500.1 | murI | HMPREF9154_0972 | HMPREF9154_0973 | Hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.815 |
| AFN46500.1 | rdgB | HMPREF9154_0972 | HMPREF9154_0975 | Hypothetical protein. | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.773 |
| AFN46907.1 | AFN44982.1 | HMPREF9154_2617 | HMPREF9154_1209 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | 0.928 |
| AFN46907.1 | AFN45610.1 | HMPREF9154_2617 | HMPREF9154_2632 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.933 |
| AFN46907.1 | gdhA | HMPREF9154_2617 | HMPREF9154_1115 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | NAD(P)-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.937 |
| AFN46907.1 | glnA | HMPREF9154_2617 | HMPREF9154_1223 | Glutamine ligase, beta-grasp domain protein; Belongs to the glutamine synthetase family. | Glutamine synthetase, type I. | 0.926 |