AFN46063.1 protein (Pseudopropionibacterium propionicum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AFN46063.1

Transporter, major facilitator family protein. (427 aa)

Predicted Functional Partners:

AFN47642.1

0.581

AFN45017.1

0.578

AFN47305.1

0.574

AFN45291.1

0.571

AFN45419.1

0.569

AFN47369.1

0.513

rbpA

0.465

AFN47750.1

0.445

AFN47651.1

0.435

AFN45179.1

0.408

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45017.1	AFN45419.1	HMPREF9154_1063	HMPREF9154_1061	Cobalt transport protein.	BioY family protein.	0.997
AFN45017.1	AFN46063.1	HMPREF9154_1063	HMPREF9154_1060	Cobalt transport protein.	Transporter, major facilitator family protein.	0.578
AFN45017.1	AFN47305.1	HMPREF9154_1063	HMPREF9154_1062	Cobalt transport protein.	ABC transporter, ATP-binding protein.	0.999
AFN45179.1	AFN46063.1	HMPREF9154_2790	HMPREF9154_1060	Hypothetical protein.	Transporter, major facilitator family protein.	0.408
AFN45291.1	AFN46063.1	HMPREF9154_1401	HMPREF9154_1060	Putative membrane protein.	Transporter, major facilitator family protein.	0.571
AFN45419.1	AFN45017.1	HMPREF9154_1061	HMPREF9154_1063	BioY family protein.	Cobalt transport protein.	0.997
AFN45419.1	AFN46063.1	HMPREF9154_1061	HMPREF9154_1060	BioY family protein.	Transporter, major facilitator family protein.	0.569
AFN45419.1	AFN47305.1	HMPREF9154_1061	HMPREF9154_1062	BioY family protein.	ABC transporter, ATP-binding protein.	0.998
AFN46063.1	AFN45017.1	HMPREF9154_1060	HMPREF9154_1063	Transporter, major facilitator family protein.	Cobalt transport protein.	0.578
AFN46063.1	AFN45179.1	HMPREF9154_1060	HMPREF9154_2790	Transporter, major facilitator family protein.	Hypothetical protein.	0.408
AFN46063.1	AFN45291.1	HMPREF9154_1060	HMPREF9154_1401	Transporter, major facilitator family protein.	Putative membrane protein.	0.571
AFN46063.1	AFN45419.1	HMPREF9154_1060	HMPREF9154_1061	Transporter, major facilitator family protein.	BioY family protein.	0.569
AFN46063.1	AFN47305.1	HMPREF9154_1060	HMPREF9154_1062	Transporter, major facilitator family protein.	ABC transporter, ATP-binding protein.	0.574
AFN46063.1	AFN47369.1	HMPREF9154_1060	HMPREF9154_1762	Transporter, major facilitator family protein.	Hypothetical protein.	0.513
AFN46063.1	AFN47642.1	HMPREF9154_1060	HMPREF9154_1036	Transporter, major facilitator family protein.	Putative membrane protein.	0.581
AFN46063.1	AFN47651.1	HMPREF9154_1060	HMPREF9154_0443	Transporter, major facilitator family protein.	Phosphoglycerate mutase family protein.	0.435
AFN46063.1	AFN47750.1	HMPREF9154_1060	HMPREF9154_2361	Transporter, major facilitator family protein.	GDSL-like protein.	0.445
AFN46063.1	rbpA	HMPREF9154_1060	HMPREF9154_1071	Transporter, major facilitator family protein.	Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.	0.465
AFN47305.1	AFN45017.1	HMPREF9154_1062	HMPREF9154_1063	ABC transporter, ATP-binding protein.	Cobalt transport protein.	0.999
AFN47305.1	AFN45419.1	HMPREF9154_1062	HMPREF9154_1061	ABC transporter, ATP-binding protein.	BioY family protein.	0.998

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.952

expected number of edges:

32

PPI enrichment p-value:

0.00288

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

6 of 36

2.57

5.59

1.05e-11

GO:0006457

Protein folding

9 of 199

2.0

5.26

2.71e-14

GO:0030968

Endoplasmic reticulum unfolded protein response

4 of 17

2.72

4.05

2.47e-08

GO:0042221

Response to chemical

8 of 257

1.84

3.98

1.76e-11

GO:0070887

Cellular response to chemical stimulus

6 of 124

2.03

3.82

2.35e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051082

Unfolded protein binding

6 of 58

2.36

4.81

1.54e-10

GO:0140662

ATP-dependent protein folding chaperone

5 of 36

2.49

4.35

3.15e-09

GO:0051787

Misfolded protein binding

4 of 14

2.8

4.11

2.27e-08

GO:0031072

Heat shock protein binding

4 of 40

2.35

3.12

8.01e-07

GO:0016972

Thiol oxidase activity

2 of 3

3.17

1.91

0.00036

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005788

Endoplasmic reticulum lumen

6 of 15

2.95

7.06

5.40e-14

GO:0034663

Endoplasmic reticulum chaperone complex

4 of 4

3.35

5.22

3.35e-10

GO:0005783

Endoplasmic reticulum

9 of 342

1.77

4.09

3.96e-13

GO:0005789

Endoplasmic reticulum membrane

4 of 211

1.63

1.69

0.00011

GO:0016020

Membrane

8 of 2717

0.82

0.74

0.00013

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30081196

(2019) Fusion to Tetrahymena thermophila granule lattice protein 1 confers solubility to sexual stage malaria antigens in Escherichia coli.

4 of 4

3.35

4.59

4.76e-09

PMID:32711561

(2020) Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies.

4 of 5

3.25

4.58

4.76e-09

PMID:34193127

(2021) Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up.

2 of 3

3.17

1.64

0.0011

PMID:32486409

(2020) Marine Biocompounds for Neuroprotection-A Review.

2 of 2

3.35

1.64

0.0011

PMID:32453970

(2020) Understanding the mammalian TRAP complex function(s).

2 of 2

3.35

1.64

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10939

Heat shock protein 70 family, and Calreticulin family

7 of 18

2.94

8.15

3.48e-16

CL:10941

Mixed, incl. Endoplasmic reticulum lumen, and Calreticulin family

6 of 13

3.01

7.37

1.61e-14

CL:10944

Mixed, incl. Calreticulin family, and Perinuclear region of cytoplasm

4 of 6

3.17

5.11

4.48e-10

CL:11390

Detoxification of Reactive Oxygen Species, and Thioredoxin, conserved site

4 of 54

2.22

3.02

8.60e-07

CL:11468

Thioredoxin, conserved site, and ERO1-like superfamily

3 of 15

2.65

2.88

4.27e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gtt04141

Protein processing in endoplasmic reticulum

10 of 129

2.24

7.96

2.85e-20

gtt03060

Protein export

4 of 26

2.54

3.9

3.19e-08

gtt04145

Phagosome

2 of 35

2.11

1.25

0.0043

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983170

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

4 of 10

2.95

4.19

1.87e-08

MAP-3371453

Regulation of HSF1-mediated heat shock response

4 of 78

2.06

2.48

8.03e-06

MAP-3371556

Cellular response to heat stress

4 of 86

2.02

2.42

9.37e-06

MAP-8953897

Cellular responses to stimuli

6 of 395

1.53

2.0

3.37e-06

MAP-2262752

Cellular responses to stress

6 of 395

1.53

2.0

3.37e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005783

Endoplasmic reticulum

8 of 197

1.96

4.58

2.08e-12

GOCC:0012505

Endomembrane system

10 of 668

1.52

3.04

2.08e-12

GOCC:0005737

Cytoplasm

11 of 3238

0.88

0.98

5.74e-08

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 2881

0.89

0.95

7.97e-07

GOCC:0043227

Membrane-bounded organelle

11 of 3415

0.86

0.94

7.72e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

4 of 17

2.72

4.02

2.89e-08

KW-0143

Chaperone

2 of 20

2.35

1.26

0.0047

KW-0256

Endoplasmic reticulum

2 of 31

2.16

1.21

0.0053

KW-0732

Signal

7 of 2732

0.76

0.56

0.0047

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06723

MreB/Mbl protein

4 of 15

2.77

3.72

1.18e-07

PF00262

Calreticulin family

2 of 2

3.35

1.73

0.00077

PF04137

Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

2 of 3

3.17

1.7

0.00085

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013126

Heat shock protein 70 family

5 of 23

2.69

4.56

2.29e-09

IPR029047

Heat shock protein 70kD, peptide-binding domain superfamily

4 of 15

2.77

3.75

1.06e-07

IPR043129

ATPase, nucleotide binding domain

5 of 50

2.35

3.72

4.04e-08

IPR018181

Heat shock protein 70, conserved site

4 of 17

2.72

3.7

1.23e-07

IPR029048

Heat shock protein 70kD, C-terminal domain superfamily

3 of 10

2.83

2.64

1.44e-05

(more ...)

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