node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFN45111.1 | dnaN | HMPREF9154_1988 | HMPREF9154_0002 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.805 |
AFN45111.1 | dut | HMPREF9154_1988 | HMPREF9154_1536 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.776 |
AFN45111.1 | thyA | HMPREF9154_1988 | HMPREF9154_0976 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.825 |
AFN45111.1 | tmk | HMPREF9154_1988 | HMPREF9154_2696 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.935 |
AFN45147.1 | AFN45375.1 | HMPREF9154_0296 | HMPREF9154_1755 | 5'-nucleotidase. | 5'-nucleotidase, C-terminal domain protein; Belongs to the 5'-nucleotidase family. | 0.900 |
AFN45147.1 | dut | HMPREF9154_0296 | HMPREF9154_1536 | 5'-nucleotidase. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
AFN45147.1 | tdk | HMPREF9154_0296 | HMPREF9154_1532 | 5'-nucleotidase. | Thymidine kinase. | 0.900 |
AFN45147.1 | thyA | HMPREF9154_0296 | HMPREF9154_0976 | 5'-nucleotidase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
AFN45147.1 | tmk | HMPREF9154_0296 | HMPREF9154_2696 | 5'-nucleotidase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
AFN45375.1 | AFN45147.1 | HMPREF9154_1755 | HMPREF9154_0296 | 5'-nucleotidase, C-terminal domain protein; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase. | 0.900 |
AFN45375.1 | dut | HMPREF9154_1755 | HMPREF9154_1536 | 5'-nucleotidase, C-terminal domain protein; Belongs to the 5'-nucleotidase family. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
AFN45375.1 | tdk | HMPREF9154_1755 | HMPREF9154_1532 | 5'-nucleotidase, C-terminal domain protein; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.919 |
AFN45375.1 | thyA | HMPREF9154_1755 | HMPREF9154_0976 | 5'-nucleotidase, C-terminal domain protein; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
AFN45375.1 | tmk | HMPREF9154_1755 | HMPREF9154_2696 | 5'-nucleotidase, C-terminal domain protein; Belongs to the 5'-nucleotidase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.911 |
AFN46967.1 | AFN47460.1 | HMPREF9154_1537 | HMPREF9154_1538 | Hypothetical protein. | Hypothetical protein. | 0.862 |
AFN46967.1 | dut | HMPREF9154_1537 | HMPREF9154_1536 | Hypothetical protein. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.832 |
AFN47460.1 | AFN46967.1 | HMPREF9154_1538 | HMPREF9154_1537 | Hypothetical protein. | Hypothetical protein. | 0.862 |
AFN47460.1 | dut | HMPREF9154_1538 | HMPREF9154_1536 | Hypothetical protein. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.833 |
dcd | dut | HMPREF9154_2847 | HMPREF9154_1536 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.920 |
dcd | thyA | HMPREF9154_2847 | HMPREF9154_0976 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.875 |