STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (535 aa)    
Predicted Functional Partners:
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
0.999
hemB
Porphobilinogen synthase; Belongs to the ALAD family.
 
 0.999
AFN46301.1
Porphobilinogen deaminase, dipyromethane cofactor-binding domain protein.
 
0.997
hemA
glutamyl-tRNAGlu reductase, N-terminal domain protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.994
hemL
Glutamate-1-semialdehyde-2,1-aminomutase.
  
 0.993
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.992
AFN46611.1
Thi4 domain protein.
  
 0.990
cobA
uroporphyrinogen-III C-methyltransferase.
  
 0.989
cobJ
precorrin-3B C(17)-methyltransferase.
  
  
 0.977
cbiX_1
Sirohydrochlorin cobaltochelatase.
 
  
 0.961
Your Current Organism:
Pseudopropionibacterium propionicum
NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a
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