AFN47515.1 protein (Pseudopropionibacterium propionicum)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

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Score

AFN47515.1

Putative membrane protein. (368 aa)

Predicted Functional Partners:

AFN47004.1

0.939

AFN45069.1

0.930

AFN47179.1

0.870

araB

0.808

AFN47738.1

0.772

AFN46089.1

0.719

AFN45898.1

0.716

AFN46139.1

0.588

AFN45395.1

0.531

AFN45316.1

0.520

Your Current Organism:

Pseudopropionibacterium propionicum

NCBI taxonomy Id: 767029
Other names: P. propionicum F0230a, Propionibacterium propionicum F0230a, Pseudopropionibacterium propionicum F0230a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFN45069.1	AFN45898.1	HMPREF9154_1853	HMPREF9154_1850	Putative ribulokinase.	Ribose 5-phosphate isomerase.	0.680
AFN45069.1	AFN46089.1	HMPREF9154_1853	HMPREF9154_2324	Putative ribulokinase.	NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	0.644
AFN45069.1	AFN46139.1	HMPREF9154_1853	HMPREF9154_1849	Putative ribulokinase.	Transcriptional regulator, DeoR family.	0.541
AFN45069.1	AFN47004.1	HMPREF9154_1853	HMPREF9154_1854	Putative ribulokinase.	Putative sn-glycerol-1-phosphate dehydrogenase.	0.963
AFN45069.1	AFN47179.1	HMPREF9154_1853	HMPREF9154_1852	Putative ribulokinase.	HAD hydrolase, family IIA; Belongs to the HAD-like hydrolase superfamily.	0.875
AFN45069.1	AFN47515.1	HMPREF9154_1853	HMPREF9154_1851	Putative ribulokinase.	Putative membrane protein.	0.930
AFN45069.1	AFN47738.1	HMPREF9154_1853	HMPREF9154_2330	Putative ribulokinase.	Alcohol dehydrogenase, iron-dependent.	0.845
AFN45069.1	araB	HMPREF9154_1853	HMPREF9154_1855	Putative ribulokinase.	Ribulokinase; Belongs to the ribulokinase family.	0.772
AFN45316.1	AFN46089.1	HMPREF9154_2325	HMPREF9154_2324	Phosphoenolpyruvate-dependent sugar PTS family porter, EIIA 2.	NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	0.727
AFN45316.1	AFN46139.1	HMPREF9154_2325	HMPREF9154_1849	Phosphoenolpyruvate-dependent sugar PTS family porter, EIIA 2.	Transcriptional regulator, DeoR family.	0.548
AFN45316.1	AFN47515.1	HMPREF9154_2325	HMPREF9154_1851	Phosphoenolpyruvate-dependent sugar PTS family porter, EIIA 2.	Putative membrane protein.	0.520
AFN45316.1	AFN47738.1	HMPREF9154_2325	HMPREF9154_2330	Phosphoenolpyruvate-dependent sugar PTS family porter, EIIA 2.	Alcohol dehydrogenase, iron-dependent.	0.622
AFN45395.1	AFN46089.1	HMPREF9154_0250	HMPREF9154_2324	NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	0.920
AFN45395.1	AFN47004.1	HMPREF9154_0250	HMPREF9154_1854	NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	Putative sn-glycerol-1-phosphate dehydrogenase.	0.956
AFN45395.1	AFN47515.1	HMPREF9154_0250	HMPREF9154_1851	NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	Putative membrane protein.	0.531
AFN45395.1	AFN47738.1	HMPREF9154_0250	HMPREF9154_2330	NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	Alcohol dehydrogenase, iron-dependent.	0.953
AFN45898.1	AFN45069.1	HMPREF9154_1850	HMPREF9154_1853	Ribose 5-phosphate isomerase.	Putative ribulokinase.	0.680
AFN45898.1	AFN46139.1	HMPREF9154_1850	HMPREF9154_1849	Ribose 5-phosphate isomerase.	Transcriptional regulator, DeoR family.	0.597
AFN45898.1	AFN47004.1	HMPREF9154_1850	HMPREF9154_1854	Ribose 5-phosphate isomerase.	Putative sn-glycerol-1-phosphate dehydrogenase.	0.685
AFN45898.1	AFN47179.1	HMPREF9154_1850	HMPREF9154_1852	Ribose 5-phosphate isomerase.	HAD hydrolase, family IIA; Belongs to the HAD-like hydrolase superfamily.	0.685

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.802

expected number of edges:

11

PPI enrichment p-value:

2.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045638

Negative regulation of myeloid cell differentiation

4 of 65

2.05

1.87

0.00019

GO:0045637

Regulation of myeloid cell differentiation

5 of 151

1.78

1.81

0.00012

GO:0045596

Negative regulation of cell differentiation

6 of 451

1.39

0.00019

GO:0007389

Pattern specification process

5 of 328

1.45

1.36

0.00039

GO:0009880

Embryonic pattern specification

3 of 55

2.0

1.34

0.0025

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

9 of 969

1.23

1.66

1.06e-07

GO:0003700

DNA-binding transcription factor activity

10 of 1187

1.19

1.64

1.60e-08

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

5 of 326

1.45

1.52

0.00010

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

9 of 1118

1.17

1.51

1.51e-07

GO:0003677

DNA binding

10 of 2214

0.92

1.0

6.34e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22829811

(2012) Epigenetic alterations in bladder cancer and their potential clinical implications.

4 of 17

2.64

2.58

1.63e-05

PMID:22495965

(2012) A novel 13 base pair insertion in the sonic hedgehog ZRS limb enhancer (ZRSLMBR1) causes preaxial polydactyly with triphalangeal thumb.

3 of 9

2.79

1.71

0.00076

PMID:26572684

(2015) Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRLMpJ mouse.

3 of 11

2.7

1.68

0.00084

PMID:36418415

(2022) The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.

3 of 13

2.63

1.64

0.00097

PMID:28874668

(2017) Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation.

3 of 19

2.46

1.45

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26589

Embryonic skeletal system morphogenesis, and N-terminal of Homeobox Meis and PKNOX1

6 of 25

2.64

5.58

1.61e-11

CL:26624

Mixed, incl. Protein of unknown function (DUF3528), and N-terminal of Homeobox Meis and PKNOX1

4 of 5

3.17

4.61

3.85e-09

CL:26433

Homeobox, and Neuron fate commitment

7 of 125

2.01

4.2

1.26e-10

CL:32174

Mixed, incl. Adiponectin binding, and G2 nidogen domain and fibulin

2 of 7

2.72

1.24

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa05202

Transcriptional misregulation in cancer

4 of 141

1.72

1.63

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 3900

0.63

0.4

0.0259

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0371

Homeobox

7 of 203

1.8

3.38

1.55e-09

KW-0238

DNA-binding

8 of 642

1.36

2.01

3.42e-08

KW-0539

Nucleus

8 of 1146

1.11

1.29

2.14e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16493

N-terminal of Homeobox Meis and PKNOX1

2 of 5

2.87

1.04

0.0130

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00389

Homeodomain

7 of 208

1.79

3.25

3.60e-09

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