| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFN45636.1 | aroB | HMPREF9154_2411 | HMPREF9154_1628 | Putative isochorismate synthase. | Putative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.486 |
| AFN45636.1 | aroC | HMPREF9154_2411 | HMPREF9154_1630 | Putative isochorismate synthase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.909 |
| AFN45636.1 | aroD | HMPREF9154_2411 | HMPREF9154_1962 | Putative isochorismate synthase. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.824 |
| AFN45636.1 | aroE | HMPREF9154_2411 | HMPREF9154_1964 | Putative isochorismate synthase. | Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.815 |
| AFN45636.1 | aroK_2 | HMPREF9154_2411 | HMPREF9154_1973 | Putative isochorismate synthase. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.608 |
| AFN45784.1 | AFN47072.1 | HMPREF9154_1963 | HMPREF9154_1972 | Transcriptional regulator, TetR family. | AP endonuclease, family 2. | 0.594 |
| AFN45784.1 | AFN47796.1 | HMPREF9154_1963 | HMPREF9154_1965 | Transcriptional regulator, TetR family. | AP endonuclease, family 2. | 0.693 |
| AFN45784.1 | aroE | HMPREF9154_1963 | HMPREF9154_1964 | Transcriptional regulator, TetR family. | Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.902 |
| AFN47072.1 | AFN45784.1 | HMPREF9154_1972 | HMPREF9154_1963 | AP endonuclease, family 2. | Transcriptional regulator, TetR family. | 0.594 |
| AFN47072.1 | AFN47796.1 | HMPREF9154_1972 | HMPREF9154_1965 | AP endonuclease, family 2. | AP endonuclease, family 2. | 0.479 |
| AFN47072.1 | aroE | HMPREF9154_1972 | HMPREF9154_1964 | AP endonuclease, family 2. | Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.696 |
| AFN47072.1 | aroK_2 | HMPREF9154_1972 | HMPREF9154_1973 | AP endonuclease, family 2. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.600 |
| AFN47796.1 | AFN45784.1 | HMPREF9154_1965 | HMPREF9154_1963 | AP endonuclease, family 2. | Transcriptional regulator, TetR family. | 0.693 |
| AFN47796.1 | AFN47072.1 | HMPREF9154_1965 | HMPREF9154_1972 | AP endonuclease, family 2. | AP endonuclease, family 2. | 0.479 |
| AFN47796.1 | aroE | HMPREF9154_1965 | HMPREF9154_1964 | AP endonuclease, family 2. | Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.772 |
| aroA | aroB | HMPREF9154_1393 | HMPREF9154_1628 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.990 |
| aroA | aroC | HMPREF9154_1393 | HMPREF9154_1630 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.998 |
| aroA | aroD | HMPREF9154_1393 | HMPREF9154_1962 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.464 |
| aroA | aroE | HMPREF9154_1393 | HMPREF9154_1964 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.947 |
| aroA | aroK_1 | HMPREF9154_1393 | HMPREF9154_1629 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.987 |