| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFN45223.1 | pepA | HMPREF9154_2096 | HMPREF9154_2097 | ABC transporter, ATP-binding protein. | Cytosol aminopeptidase family, catalytic domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.474 |
| AFN46516.1 | AFN46935.1 | HMPREF9154_2099 | HMPREF9154_2098 | NmrA domain protein. | Transcriptional regulator, TetR family. | 0.886 |
| AFN46516.1 | pepA | HMPREF9154_2099 | HMPREF9154_2097 | NmrA domain protein. | Cytosol aminopeptidase family, catalytic domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.517 |
| AFN46689.1 | cysK | HMPREF9154_2862 | HMPREF9154_2131 | Aminotransferase, class I/II. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.938 |
| AFN46689.1 | metH | HMPREF9154_2862 | HMPREF9154_1608 | Aminotransferase, class I/II. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.941 |
| AFN46689.1 | pepA | HMPREF9154_2862 | HMPREF9154_2097 | Aminotransferase, class I/II. | Cytosol aminopeptidase family, catalytic domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.809 |
| AFN46689.1 | pepN | HMPREF9154_2862 | HMPREF9154_1869 | Aminotransferase, class I/II. | Membrane alanyl aminopeptidase. | 0.800 |
| AFN46935.1 | AFN46516.1 | HMPREF9154_2098 | HMPREF9154_2099 | Transcriptional regulator, TetR family. | NmrA domain protein. | 0.886 |
| AFN46935.1 | pepA | HMPREF9154_2098 | HMPREF9154_2097 | Transcriptional regulator, TetR family. | Cytosol aminopeptidase family, catalytic domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.444 |
| cysK | AFN46689.1 | HMPREF9154_2131 | HMPREF9154_2862 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Aminotransferase, class I/II. | 0.938 |
| cysK | glyA | HMPREF9154_2131 | HMPREF9154_0694 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Putative glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.484 |
| cysK | metH | HMPREF9154_2131 | HMPREF9154_1608 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.933 |
| cysK | pepA | HMPREF9154_2131 | HMPREF9154_2097 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cytosol aminopeptidase family, catalytic domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.831 |
| cysK | pepN | HMPREF9154_2131 | HMPREF9154_1869 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Membrane alanyl aminopeptidase. | 0.818 |
| gcvP | glyA | HMPREF9154_1903 | HMPREF9154_0694 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
| gcvP | metH | HMPREF9154_1903 | HMPREF9154_1608 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.926 |
| gcvP | pepA | HMPREF9154_1903 | HMPREF9154_2097 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Cytosol aminopeptidase family, catalytic domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.558 |
| glyA | cysK | HMPREF9154_0694 | HMPREF9154_2131 | Putative glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.484 |
| glyA | gcvP | HMPREF9154_0694 | HMPREF9154_1903 | Putative glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
| glyA | gmk | HMPREF9154_0694 | HMPREF9154_1620 | Putative glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.482 |
